PDF(Pubmed)
Abstract：
BACKGROUND: Aim of this study was to detect predictors of better adherence to the AgeWell.de-intervention, a two-year randomized multi-domain lifestyle intervention against cognitive decline.
METHODS: Data of 317 intervention group-participants comprising a risk group for dementia (Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) score of ≥ 9; mean age 68.9 years, 49.5% women) from the AgeWell.de intervention study were analysed. Regression models with four blocks of predictors (sociodemographic, cognitive and psychosocial, lifestyle factors and chronic conditions) were run on adherence to the components of nutrition, enhancement of social and physical activity and cognitive training. Adherence to each component was operationalised by assessing the degree of goal achievement per component at up to seven time points during the intervention period, measured using a 5-point Likert scale (mean score of goal achievement).
RESULTS: Increasing age was negatively associated with adherence, while higher education positively predicted adherence. Participants with better mental state (Montreal Cognitive Assessment (MoCA)-score > 25) at baseline and higher self-efficacy adhered better. Diabetes and cardiovascular conditions were not associated with adherence, whereas smoking negatively affected adherence. Highest education and quitting smoking in the past were the only predictors associated with all four intervention components.
CONCLUSIONS: Results identified predictors for better and worse adherence. Particularly self-efficacy seems to be of considerable influence on adherence. This should be considered when designing future intervention trials.
BACKGROUND: German Clinical Trials Register (ref. number: DRKS00013555).
METHODS: Data of 317 intervention group-participants comprising a risk group for dementia (Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) score of ≥ 9; mean age 68.9 years, 49.5% women) from the AgeWell.de intervention study were analysed. Regression models with four blocks of predictors (sociodemographic, cognitive and psychosocial, lifestyle factors and chronic conditions) were run on adherence to the components of nutrition, enhancement of social and physical activity and cognitive training. Adherence to each component was operationalised by assessing the degree of goal achievement per component at up to seven time points during the intervention period, measured using a 5-point Likert scale (mean score of goal achievement).
RESULTS: Increasing age was negatively associated with adherence, while higher education positively predicted adherence. Participants with better mental state (Montreal Cognitive Assessment (MoCA)-score > 25) at baseline and higher self-efficacy adhered better. Diabetes and cardiovascular conditions were not associated with adherence, whereas smoking negatively affected adherence. Highest education and quitting smoking in the past were the only predictors associated with all four intervention components.
CONCLUSIONS: Results identified predictors for better and worse adherence. Particularly self-efficacy seems to be of considerable influence on adherence. This should be considered when designing future intervention trials.
BACKGROUND: German Clinical Trials Register (ref. number: DRKS00013555).
摘要：
背景：这项研究的目的是检测更好地坚持AgeWell的预测因子。去干预，一项为期两年的针对认知下降的多领域生活方式随机干预。
方法：317名干预组参与者的数据包括痴呆风险组（心血管危险因素，老年和痴呆（CAIDE）评分≥9；平均年龄68.9岁，49.5%的女性）来自AgeWell。对去干预研究进行了分析。具有四个预测因子块的回归模型(社会人口统计学，认知和社会心理，生活方式因素和慢性病)是基于对营养成分的坚持，加强社会和体育活动和认知训练。通过在干预期间最多七个时间点评估每个组件的目标实现程度，来实施对每个组件的坚持。使用5分Likert量表（目标成就的平均得分）进行测量。
结果：年龄增长与依从性呈负相关，而高等教育积极预测坚持。基线时精神状态较好（蒙特利尔认知评估（MoCA）评分>25）和自我效能感较高的参与者表现更好。糖尿病和心血管疾病与依从性无关，而吸烟对依从性有负面影响。过去最高的教育和戒烟是与所有四个干预因素相关的唯一预测因素。
结论：结果确定了依从性好和差的预测因素。特别是自我效能感似乎对依从性有相当大的影响。在设计未来的干预试验时应考虑这一点。
背景：德国临床试验注册（参考编号:DRKS00013555)。
方法：317名干预组参与者的数据包括痴呆风险组（心血管危险因素，老年和痴呆（CAIDE）评分≥9；平均年龄68.9岁，49.5%的女性）来自AgeWell。对去干预研究进行了分析。具有四个预测因子块的回归模型(社会人口统计学，认知和社会心理，生活方式因素和慢性病)是基于对营养成分的坚持，加强社会和体育活动和认知训练。通过在干预期间最多七个时间点评估每个组件的目标实现程度，来实施对每个组件的坚持。使用5分Likert量表（目标成就的平均得分）进行测量。
结果：年龄增长与依从性呈负相关，而高等教育积极预测坚持。基线时精神状态较好（蒙特利尔认知评估（MoCA）评分>25）和自我效能感较高的参与者表现更好。糖尿病和心血管疾病与依从性无关，而吸烟对依从性有负面影响。过去最高的教育和戒烟是与所有四个干预因素相关的唯一预测因素。
结论：结果确定了依从性好和差的预测因素。特别是自我效能感似乎对依从性有相当大的影响。在设计未来的干预试验时应考虑这一点。
背景：德国临床试验注册（参考编号:DRKS00013555)。
