PDF(Pubmed)
Abstract：
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a factor that implicate in the pathophysiology and treatment of depression and anxiety. The aim of this study was to determine the relationship between dental anxiety and BDNF serum level through impacted third molar surgery.
METHODS: In this randomized, double-blind, cross-sectional study, the sample included patients who had been admitted for the impacted third molar extraction under local anesthesia between January to November 2020. The primary predictor variable was serum BDNF level and the second predictor variable was dental anxiety scores before and after operation in patients. The primary outcome variable was the correlation between anxiety scores (APAIS, MDAS, STAI, VAS) and serum BDNF level. The sample included 55 patients (22 Male, 33 Female) aged 18 to 42 (24,2+5,55).
RESULTS: Comparison of pre-operative scores (APAIS, MDAS, STAI, VAS and BDNF) and post-operative scores were statistically significant (P < .05). Post-operatively, MDAS and VAS scores decreased, while BDNF levels and STAI scores increased compared to the preoperative scores. BDNF was not correlated with APAIS, MDAS, STAI, and VAS preoperatively and postoperatively.
CONCLUSIONS: There may be a relationship between serum BDNF level and dental anxiety scale, but, no correlation was found between them.
METHODS: In this randomized, double-blind, cross-sectional study, the sample included patients who had been admitted for the impacted third molar extraction under local anesthesia between January to November 2020. The primary predictor variable was serum BDNF level and the second predictor variable was dental anxiety scores before and after operation in patients. The primary outcome variable was the correlation between anxiety scores (APAIS, MDAS, STAI, VAS) and serum BDNF level. The sample included 55 patients (22 Male, 33 Female) aged 18 to 42 (24,2+5,55).
RESULTS: Comparison of pre-operative scores (APAIS, MDAS, STAI, VAS and BDNF) and post-operative scores were statistically significant (P < .05). Post-operatively, MDAS and VAS scores decreased, while BDNF levels and STAI scores increased compared to the preoperative scores. BDNF was not correlated with APAIS, MDAS, STAI, and VAS preoperatively and postoperatively.
CONCLUSIONS: There may be a relationship between serum BDNF level and dental anxiety scale, but, no correlation was found between them.
摘要：
背景：脑源性神经营养因子（BDNF）是一种与抑郁和焦虑的病理生理和治疗有关的因子。这项研究的目的是通过阻生第三磨牙手术确定牙科焦虑与BDNF血清水平之间的关系。
方法：在本随机分组中，双盲,横断面研究，样本包括在2020年1月至11月期间在局部麻醉下接受阻生第三磨牙拔除术的患者.主要预测变量为血清BDNF水平,第二预测变量为患者手术前后牙科焦虑评分。主要结果变量是焦虑评分之间的相关性(APAIS，MDAS,STAI,VAS)和血清BDNF水平。样本包括55名患者(22名男性，33名女性)18至42岁(24,2+5,55)。
结果：术前评分的比较（APAIS，MDAS,STAI,VAS和BDNF)及术后评分差异有统计学意义(P<0.05)。术后,MDAS和VAS评分下降，而BDNF水平和STAI评分与术前评分相比增加。BDNF与APAIS无相关性,MDAS,STAI,术前和术后VAS。
结论：血清BDNF水平可能与牙科焦虑量表有关，但是,两者之间没有相关性。
方法：在本随机分组中，双盲,横断面研究，样本包括在2020年1月至11月期间在局部麻醉下接受阻生第三磨牙拔除术的患者.主要预测变量为血清BDNF水平,第二预测变量为患者手术前后牙科焦虑评分。主要结果变量是焦虑评分之间的相关性(APAIS，MDAS,STAI,VAS)和血清BDNF水平。样本包括55名患者(22名男性，33名女性)18至42岁(24,2+5,55)。
结果：术前评分的比较（APAIS，MDAS,STAI,VAS和BDNF)及术后评分差异有统计学意义(P<0.05)。术后,MDAS和VAS评分下降，而BDNF水平和STAI评分与术前评分相比增加。BDNF与APAIS无相关性,MDAS,STAI,术前和术后VAS。
结论：血清BDNF水平可能与牙科焦虑量表有关，但是,两者之间没有相关性。
