Dental Anxiety

牙科焦虑
  • 文章类型: Journal Article
    背景:药理学方法,特别是镇静剂,在牙科预约期间管理儿童的行为方面越来越受欢迎。
    目的:本研究的目的是比较1m/kg鼻内右美托咪定,0.3mg/kg鼻内咪达唑仑,和一氧化二氮在评估镇静水平时,孩子的行为,开始镇静,生理体征,和不利影响。
    方法:在这项交叉试验中,15名6-8岁儿童随机接受鼻内雾化右美托咪定,鼻内雾化咪达唑仑,和吸入一氧化二氮在三个不同的访问。服用镇静剂后,在每次预约期间进行一次牙髓切除术,并记录结果.每次访问之间的清除期为1周。
    结果:所有三种镇静剂在控制总体行为方面同样有效。右美托咪定的镇静水平评分(激动;评分9)低于其他组。镇静的开始有统计学上的显著差异,右美托咪定的最长起效时间为36.2±9.47分钟。鼻内咪达唑仑给药后主要观察到咳嗽和打喷嚏。在局部麻醉给药和治疗后,鼻内咪达唑仑组的氧饱和度水平在统计学上较低。
    结论:0.3mg/kg的咪达唑仑鼻内镇静与一氧化二氮镇静同样有效,可以控制儿童牙科患者的行为并提供足够的镇静。然而,1m/kg右美托咪定不能提供相同的镇静水平,并且起效时间明显更长。0.3mg/kg鼻内咪达唑仑是焦虑儿童一氧化二氮镇静的有效替代药物。
    BACKGROUND: Pharmacological methods, specifically sedatives, have gained popularity in managing the behavior of children during dental appointments.
    OBJECTIVE: The aim of this study was to compare 1 m/kg intranasal dexmedetomidine, 0.3 mg/kg intranasal midazolam, and nitrous oxide in evaluating the level of sedation, behavior of the child, onset of sedation, physiologic signs, and adverse effects.
    METHODS: In this cross-over trial, 15 children aged 6-8 years were randomized to receive intranasal atomized dexmedetomidine, intranasal atomized midazolam, and inhalation nitrous oxide at three separate visits. After administering the sedative agent, a single pulpectomy was performed during each appointment, and the outcomes were recorded. The washout period between each visit was 1 week.
    RESULTS: All three sedative agents were equally effective in controlling overall behavior. Dexmedetomidine showed lower sedation level scores (agitated; score 9) than the other groups. There was a statistically significant difference in the onset of sedation, with dexmedetomidine having the longest onset of 36.2 ± 9.47 min. Coughing and sneezing were predominantly observed after administration of intranasal midazolam. Oxygen saturation levels were statistically lower in the intranasal midazolam group during local anesthesia administration and post-treatment.
    CONCLUSIONS: 0.3 mg/kg intranasal midazolam is as effective as nitrous oxide sedation for controlling behavior and providing adequate sedation in pediatric dental patients. However, 1 m/kg dexmedetomidine did not provide the same level of sedation and had a significantly longer onset. 0.3 mg/kg intranasal midazolam is an effective alternative to nitrous oxide sedation in anxious children.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:龋齿是一种多因素疾病,表现为原发性和永久性牙列。凹坑和裂缝密封剂已成为解决儿童深凹坑和裂缝的最有效的非侵入性治疗方法。本研究的目的是评估使用橡胶坝和MiniDam施用窝沟密封剂时儿童的行为。
    方法:将52名9-12岁的儿童随机分为两组:I组,橡胶坝和第二组,MiniDam.将儿童随机分为两组,第1组(橡胶坝隔离)有26名成员,第2组(MiniDam隔离)有26名成员。使用改良的Venham量表和心率评估儿童的焦虑。使用Memojis疼痛量表评估儿童的疼痛强度。收集的数据采用SPSS软件进行统计和分析。显著性水平建立在0.05。
    结果:组间心率比较显示两组在不同时间间隔的差异有统计学意义(P值0.05),也就是说,在放置大坝之前,有了大坝,在治疗期间。两组患者术前、术后疼痛、焦虑评分差异均有统计学意义(P<0.05)。
    结论:由于其独特的品质,MiniDam的使用可以为坑/裂缝密封剂程序提供更好的选择,包括放置的简单性,改进行为管理,儿童的椅子时间更少。
    BACKGROUND: Dental caries is a multifactorial disease that manifests itself in primary and permanent dentitions. Pit and fissure sealants have become the most effective noninvasive treatment for addressing teeth with deep pits and fissures in children. The purpose of the present study was to evaluate the behavior of the child when administering the pit and fissure sealant using the rubber dam and MiniDam.
    METHODS: Fifty-two children in the age range of 9-12 years were randomly allocated into two groups: Group I, rubber dam and Group II, MiniDam. The children were randomly assigned into two groups with 26 members in Group 1 (rubber dam isolation) and 26 members in Group 2 (MiniDam isolation). Children\'s anxiety was assessed using the modified Venham scale and heart rate. The children\'s pain intensity was assessed using Memojis Pain Scale. The data collected were tabulated and statistically analyzed using SPSS software. The level of significance was established at 0.05.
    RESULTS: Intergroup comparison of heart rates showed a statistically significant difference for both the groups at various intervals (P value 0.05), that is, before placing the dam, with the dam, and during treatment. Pain and anxiety scores showed a statistically significant difference in both the groups before and after the procedure (P < 0.05).
    CONCLUSIONS: The use of MiniDam can offer a better option for the pit/fissure sealant procedure due to its unique qualities, including simplicity of placement, improved behavior management, and less chair time in children.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    目标:美洲印第安人和阿拉斯加本地人(AI/AN)表示对医疗保健系统不信任。这项研究探讨了AI/AN成人中高水平的牙科不信任或高水平的牙科护理相关恐惧和焦虑(“牙科焦虑”)与口腔健康结果之间的关联。
    方法:2022年美国口腔健康公平状况调查包括改良牙科焦虑量表,并询问受访者在多大程度上同意该声明,“在我最后一次口腔健康访问中,我信任我看到的口腔健康提供者,”并询问了自我评估的口腔健康和牙科之家的存在。
    结果:报告牙齿信任度低(n=110)或牙齿焦虑高(MDAS≥19;n=113)的AI/AN个体(N=564)报告的总体和口腔健康状况明显恶化,并且拥有牙科之家的可能性显着降低(每种分析均使用p<0.05)。
    结论:牙科不信任和牙科焦虑可以显着影响AI/AN社区的口腔健康和牙科利用,并且是改善AI/AN口腔健康的重要干预目标。
    OBJECTIVE: American Indian and Alaska native (AI/AN) individuals report distrust of the healthcare system. This study explored associations between having either high levels of dental distrust or high levels of dental care-related fear and anxiety (\"dental anxiety\") and oral health outcomes in AI/AN adults.
    METHODS: The 2022 State of Oral Health Equity in America survey included the Modified Dental Anxiety Scale and asked to what extent respondents agreed with the statement, \"At my last oral health visit, I trusted the oral health provider I saw\", and asked about self-rated oral health and presence of a dental home.
    RESULTS: AI/AN individuals (N = 564) who reported low dental trust (n = 110) or with high dental anxiety (MDAS≥19; n = 113) reported significantly worse overall and oral health and were significantly less likely to have a dental home (p < 0.05 used for each analysis).
    CONCLUSIONS: Dental distrust and dental anxiety can significantly impact oral health and dental utilization in AI/AN communities and are important intervention targets to improve AI/AN oral health.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    目的:在系统评价和荟萃分析中探讨6至12岁儿童的牙科恐惧与龋齿之间的关系。
    方法:根据医学主题词(MeSH)或非MeSH选择系统评价搜索词。在Scopus进行了一项以英文发表的研究的电子搜索,该研究评估了牙科恐惧(儿童恐惧调查时间表-牙科子量表)与龋齿(DMFT或dmft指数)之间的关系,WebofScience,PubMed,Embase,截至2022年3月的Cochrane和Proquest数据库。在最初检索的5759篇文章中,16人符合纳入研究的条件,其中5例纳入定量分析。根据纽卡斯尔-渥太华量表评估研究质量。Begg检验用于评估发表偏倚。
    结果:根据荟萃分析,结果显示,在低和高恐惧评分组中,DMFT评分的平均值没有统计学上的显著差异,平均差为1.28(95%置信区间-0.132至2.693)(P=0.076)。在低恐惧得分和高恐惧得分组的平均dmft得分上发现有统计学上的显著差异,平均差0.227(95%置信区间0.058至0.395)(P=0.008)。高恐惧评分组的平均dmft明显更高。
    结论:牙科恐惧与乳牙龋齿有显著关系,但不是恒牙。
    OBJECTIVE: To investigate the relationship between dental fear and dental caries in children aged 6 to 12 years in a systematic review and meta-analysis.
    METHODS: Systematic review search terms were selected according to medical subject headings (MeSH) or non-MeSH. An electronic search of studies published in English assessing the relationship between dental fear (children\'s fear survey schedule-dental subscale) and dental caries (DMFT or dmft index) was carried out of the Scopus, Web of Science, PubMed, Embase, Cochrane and Proquest databases up to March 2022. Of 5,759 articles retrieved initially, 16 were eligible for inclusion in the study, and 5 of these were included in the quantitative analysis. The quality of studies was evaluated based on the Newcastle-Ottawa scale. Begg tests were employed to assess the publication bias.
    RESULTS: According to the meta-analysis, the results revealed no statistically significant difference in mean of DMFT score in low and high fear score groups, with a mean difference of 1.28 (95% confidence interval -0.132 to 2.693) (P = 0.076). A statistically significant difference was found in the mean dmft score for the low and high fear score groups, with a mean difference of 0.227 (95% confidence interval 0.058 to 0.395) (P = 0.008). The mean dmft was significantly higher in the high fear score group.
    CONCLUSIONS: Dental fear has a significant relationship with caries in primary teeth, but not in permanent teeth.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    这篇综述评估了干预成人状态焦虑(牙科治疗期间的恐惧和情绪困扰)的随机对照试验(RCT),慢性牙科(特质焦虑)或牙科恐惧症(不成比例的高特质焦虑;符合特定恐惧症的诊断标准)。系统检索了7个在线数据库。173项RCT符合纳入标准,其中67人符合14项汇总分析的资格。为了减轻口腔手术期间的状态焦虑,中度确定性证据支持使用催眠(SMD=-0.31,95CI[-0.56,-0.05]),低确定性证据支持使用苯二氮卓类药物(SMD=-0.43,[-0.74,-0.12])。关于心理治疗,减少状态焦虑的证据尚无定论,并且不支持虚拟现实暴露疗法(VRET),虚拟现实分心,音乐,芳香疗法,视频信息和针灸。为了减少特质焦虑,中度确定性证据支持使用认知行为疗法(CBT;SMD=-0.65,[-1.06,-0.24])。关于牙科恐惧症,具有低到中等确定性的证据支持采用心理治疗(SMD=-0.48,[-0.72,-0.24]),特别是CBT(SMD=-0.43,[-0.68,-0.17]),但不是VRET。这些结果表明牙齿焦虑是可控制和可治疗的。临床医生应确保干预措施符合他们在治疗期间管理急性情绪的目的,或缓解慢性焦虑和回避倾向。现有的研究差距强调了未来试验最小化偏倚和遵循CONSORT报告指南的必要性。
    This review evaluates randomized controlled trials (RCTs) intervening on adult state anxiety (fear and emotional distress during dental treatment), chronic dental (trait) anxiety or dental phobia (disproportionately high trait anxiety; meeting diagnostic criteria for specific phobia). Seven online databases were systematically searched. 173 RCTs met inclusion criteria, of which 67 qualified for 14 pooled analyses. To alleviate state anxiety during oral surgery, moderate-certainty evidence supports employing hypnosis (SMD=-0.31, 95 %CI[-0.56,-0.05]), and low-certainty evidence supports prescribing benzodiazepines (SMD=-0.43, [-0.74,-0.12]). Evidence for reducing state anxiety is inconclusive regarding psychotherapy, and does not support virtual reality exposure therapy (VRET), virtual reality distraction, music, aromatherapy, video information and acupuncture. To reduce trait anxiety, moderate-certainty evidence supports using Cognitive Behavioral Therapy (CBT; SMD=-0.65, [-1.06, -0.24]). Regarding dental phobia, evidence with low-to-moderate certainty supports employing psychotherapy (SMD=-0.48, [-0.72,-0.24]), and CBT specifically (SMD=-0.43, [-0.68,-0.17]), but not VRET. These results show that dental anxieties are manageable and treatable. Clinicians should ensure that interventions match their purpose-managing acute emotions during treatment, or alleviating chronic anxiety and avoidance tendencies. Existing research gaps underscore the necessity for future trials to minimize bias and follow CONSORT reporting guidelines.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:母亲通常在抚养孩子和发展与健康相关的行为中起主要作用。本研究旨在评估母亲和儿童牙齿焦虑与口腔卫生状况之间的关系。
    方法:该研究包括305名儿童,4-12岁,第一次来看牙医的人和他们的母亲。所有人口统计学和口腔卫生信息均通过问卷收集。使用改良牙科焦虑量表(MDAS)和Venham图片测试(VPT)评估母亲和儿童的牙科焦虑,分别。对母亲和孩子进行了口腔检查,和他们的PI,GI,并记录DMFT评分。
    结果:尽管MDAS和VPT之间的相关性在8-12岁的儿童中呈正相关且强,但在4-7岁的儿童中呈正相关,但较弱。检测到母亲的PI之间存在显著关系,GI,DMFT,和孩子的VPT分数。根据母亲的牙齿焦虑,PI无统计学差异,GI,以及4至7岁儿童的dmft值。在8-12岁的儿童中,发现母亲的牙科焦虑与儿童的DMFT之间存在中等正统计学意义的关系。
    结论:儿童牙科焦虑受母亲牙科焦虑的显著影响,母亲经历的治疗后并发症,以及母亲的口腔健康状况。
    背景:临床试验ID:NCT05563532;注册日期:17.09.2022。
    BACKGROUND: Mothers usually have the primary role in raising children and developing health-related behaviors. This study aims to evaluate the relationship between dental anxiety and oral hygiene status of mothers and children\'s dental anxiety and gingival health.
    METHODS: The study included 305 children, aged 4-12 years, who came to the dentist for the first time and their mothers. All the demographic and oral hygiene information were collected through a questionnaire. The dental anxiety of the mothers and children was assessed using the Modified Dental Anxiety Scale (MDAS) and Venham Picture Test (VPT), respectively. The oral examination of the mother and children was performed, and their PI, GI, and DMFT scores were recorded.
    RESULTS: While the correlation between MDAS and VPT was positive and strong in children aged 8-12, it was positive but weak in the 4-7 age group. A significant relationship was detected between the mother\'s PI, GI, DMFT, and the child\'s VPT score. According to the mothers\' dental anxiety, there were no statistically significant differences in PI, GI, and dmft values in children aged between 4 to 7. A moderately positive and statistically significant relationship between maternal dental anxiety and children\'s DMFT was identified in children aged 8-12.
    CONCLUSIONS: Children\'s dental anxiety was significantly influenced by maternal dental anxiety, post-treatment complications experienced by the mother, and the oral health status of the mother.
    BACKGROUND: Clinical Trials-ID: NCT05563532; Registration Date: 17.09.2022.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Letter
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:近年来,使用矫正器进行正畸治疗的需求增加了,由病人的需要,因为对准器通常为它们提供改进的美学和更少的身体不适。在与患者一起决定适当的正畸系统时,重要的是要考虑到潜在的不适和患者对治疗的看法。这项研究的目的是分析支架或矫正器对治疗第一个月的成年患者样本中口腔健康相关生活质量(OHRQoL)和焦虑水平的影响。
    方法:试点研究于2023年11月至2024年2月在萨拉曼卡大学牙科诊所进行。选择了80名开始正畸治疗的成年患者,并将其分为两组:托槽组(Victory®;3MUnitek,加州,美国)(n=40)和对准器组(Invisalign®;对准技术,加州,美国)(n=40)。OHRQoL使用口腔健康影响概况-14(OHIP-14)问卷进行分析,使用状态特质焦虑量表(STAI)分析焦虑。随访时间为一个月,在开始(T0)和开始治疗后一个月(T1)记录评分。
    结果:患者平均年龄为33.70(±5.45)岁。总样本(n=80)包括66.2%的男性和33.8%的女性。在括号组中,开始治疗一个月后,影响最大的维度是身体疼痛(5.62±1.51)。在校准器组中,其中心理残疾维度得分最高(4.22±1.02)。在支架组中,OHIP总评分在1个月(T1)(33.98±6.81)高于治疗开始时(T0)(21.80±3.34);在开始治疗后一个月,未观察到对OHRQoL的更大影响(T1=27.33±6.83;T0=27.33±6.22)。使用的正畸系统不影响参与者的焦虑(p>0.05)。年龄和性别不是OHRQoL和焦虑的影响因素。
    结论:支架系统显著影响患者OHRQoL。在研究的样本中,未观察到正畸系统(托槽与矫正器)对焦虑的影响。
    BACKGROUND: In recent years, the demand for orthodontic treatment with aligners has increased, led by patient need, as aligners typically provide them with improved aesthetics and less physical discomfort. In deciding with the patient on an appropriate orthodontic system, it is important to take into account the potential discomfort and the perceptions that patients have in relation to their treatment. The objective of this study was to analyze the influence of brackets or aligners on oral health-related quality of life (OHRQoL) and anxiety levels in a sample of adult patients during the first month of treatment.
    METHODS: The pilot study was carried out at the Dental Clinic of the University of Salamanca between November 2023 and February 2024. Eighty adult patients who initiated orthodontic treatment were selected and divided into two groups: the brackets group (Victory®; 3 M Unitek, California, USA) (n = 40) and the aligners group (Invisalign®; Align Technology, California, USA) (n = 40). OHRQoL was analyzed using the Oral Health Impact Profile-14 (OHIP-14) questionnaire, and anxiety was analyzed using the State-Trait Anxiety Inventory (STAI). The follow-up time was one month, with scores recorded at the beginning (T0) and one month after starting treatment (T1).
    RESULTS: The mean patient age was 33.70 (± 5.45) years old. The total sample (n = 80) consisted of 66.2% men and 33.8% women. In the brackets group, one month after starting treatment, the dimension with the highest impact was that of physical pain (5.62 ± 1.51). In the aligners group, where the dimension of psychological disability had the highest score (4.22 ± 1.02). In the brackets group the total OHIP score was higher at one month (T1) (33.98 ± 6.81) than at the start of treatment (T0) (21.80 ± 3.34); this greater impact on OHRQoL one month after starting treatment was not observed in the aligners group (T1 = 27.33 ± 6.83; T0 = 27.33 ± 6.22). The orthodontic system used did not influence participants\' anxiety (p > 0.05). Age and sex were not influential factors in either OHRQoL or anxiety.
    CONCLUSIONS: The bracket system significantly influenced patients\' OHRQoL. In the sample studied, no influence of the orthodontic system (brackets versus aligners) on anxiety was observed.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    这项前瞻性研究旨在评估牙齿疼痛,焦虑,以及接受根管治疗的孕妇的灾难性水平。该研究包括60名出现牙痛和根管治疗适应症的孕妇和非孕妇。使用经过验证的问卷调查了牙科焦虑和灾难。进行了牙髓干预,和测量术前和术后牙痛的数字量表。结果采用STATA软件12.0进行分析。未经调整的分析评估了怀孕和疼痛之间的关联,焦虑,和灾难性的水平。使用“正向逐步”进入程序的多元线性回归模型用于评估变量对疼痛评分的独立影响。显著性水平设定为0.05。最初,大多数患者经历了剧烈的牙齿疼痛。牙齿疼痛的程度,牙科焦虑,孕妇和非孕妇之间的灾难没有差异。Logistic回归分析显示,术后疼痛与不可逆牙髓炎诊断(OR=4.78;95CI1.55-13.55)和高灾难性水平(OR=1.96;95CI1.01-3.84)相关。孕妇和非孕妇的术前和术后疼痛率以及焦虑和恐惧相似。术后疼痛与不可逆牙髓炎诊断和高灾难化水平有关。孕妇和非孕妇在术前和术后牙痛以及恐惧和焦虑水平方面的相似性支持在必要时在妊娠期进行根管治疗的指征。
    This prospective study aims to evaluate dental pain, anxiety, and catastrophizing levels in pregnant women undergoing root canal treatment. Sixty pregnant and non-pregnant women presenting dental pain and an indication for root canal treatment were included in the study. Dental anxiety and catastrophizing were investigated using validated questionnaires. The endodontic intervention was performed, and a numerical scale measured preoperative and postoperative dental pain. The results were analyzed using STATA software 12.0. Unadjusted analyses assessed the association between pregnancy and pain, anxiety, and catastrophizing levels. Multiple linear regression models using \'forward stepwise\' entry procedures were used to assess the independent effects of variables on pain scores. The significance level was set at 0.05. Initially, most patients experienced intense dental pain. The levels of dental pain, dental anxiety, and catastrophizing did not differ between pregnant and non-pregnant women. Logistic regression showed that postoperative pain was associated with irreversible pulpitis diagnosis (OR = 4.78; 95%CI 1.55-13.55) and high catastrophizing levels (OR = 1.96; 95%CI 1.01-3.84). Preoperative and postoperative pain rates and anxiety and catastrophizing were similar between pregnant and non-pregnant patients. Postoperative pain was associated with irreversible pulpitis diagnosis and high catastrophizing levels. The similarity between pregnant and non-pregnant women regarding preoperative and postoperative dental pain and catastrophizing and anxiety levels supports the indication of root canal treatment during the gestational period whenever necessary.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:恐惧和焦虑是对不愉快刺激的常见心理反应,牙齿恐惧是第四种最普遍的恐惧或恐惧症。然而,不是所有的牙科手术都会引起同样程度的焦虑,牙科手术和拔牙是该领域最可怕的五大手术之一。拔牙也是牙科手术中最常见的外科手术。通过确定主要因素来管理牙科诊所的焦虑非常重要。
    方法:本研究是对一组250名患者进行的。本研究采用疼痛控制问卷(BPCQ)的调查技术和信念。在拔牙手术之前和之后,在视觉模拟量表(VAS)上测量了每位患者的疼痛和压力强度。
    结果:年轻女性和小城镇的人焦虑程度最高。导致焦虑程度最高的因素是对并发症的恐惧。接受拔除保留牙齿的患者的焦虑水平较高。
    结论:围手术期应激强烈依赖于多种因素。为了患者的舒适,对于牙医来说,了解这些因素以及利用它们减少拔牙前后压力的能力可能是至关重要的。
    BACKGROUND: Fear and anxiety are common psychological responses to unpleasant stimuli, with dental fear being the fourth most prevalent type of fear or phobia. However, not all dental procedures cause the same level of anxiety, with dental surgery and tooth extraction being among the top five most frightening procedures in the field. Tooth extractions are also the most common surgical procedure in dental surgery. It is important to manage anxiety in the dental office by identifying the main factors.
    METHODS: The study was conducted on a group of 250 patients. The survey technique and the Beliefs about Pain Control Questionnaire (BPCQ) were used in the study. Pain and stress intensity on a Visual Analog Scale (VAS) were measured in each patient before and after tooth extraction procedures.
    RESULTS: Young women and people from small towns had the highest levels of anxiety. The factor causing the highest level of anxiety was fear of complications. Patients undergoing extraction of retained teeth were characterized by higher levels of anxiety.
    CONCLUSIONS: Perioperative stress is strongly dependent on numerous factors. For patient comfort, it may be crucial for dentists to have knowledge about these factors and the ability to utilize them to reduce stress before and after tooth extractions.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号