PDF(Pubmed)
Abstract：
BACKGROUND: Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth disorders, neuromuscular problems, impaired motor coordination, and decreased muscle tone. However, it is not known whether loss of muscle strength occurs, and which interventions will effectively mitigate physical PAE impairments. We aimed to investigate whether physical alteration persists during adolescence and whether exercise is an effective intervention.
RESULTS: Using paradigms to evaluate different physical qualities, we described that early adolescent PAE animals have significant alterations in agility and strength, without alterations in balance and coordination compared to CTRL animals. We evaluated the effectiveness of 3 different exercise protocols for 4 weeks: Enrichment environment (EE), Endurance exercise (EEX), and Resistance exercise (REX). The enriched environment significantly improved the strength in the PAE group but not in the CTRL group whose strength parameters were maintained even during exercise. Resistance exercise showed the greatest benefits in gaining strength, and endurance exercise did not.
CONCLUSIONS: PAE induced a significant decrease in strength compared to CTRL in PND21. Resistance exercise is the most effective to reverse the effects of PAE on muscular strength. Our data suggests that individualized, scheduled, and supervised training of resistance is more beneficial than endurance or enriched environment exercise for adolescents FASD.
RESULTS: Using paradigms to evaluate different physical qualities, we described that early adolescent PAE animals have significant alterations in agility and strength, without alterations in balance and coordination compared to CTRL animals. We evaluated the effectiveness of 3 different exercise protocols for 4 weeks: Enrichment environment (EE), Endurance exercise (EEX), and Resistance exercise (REX). The enriched environment significantly improved the strength in the PAE group but not in the CTRL group whose strength parameters were maintained even during exercise. Resistance exercise showed the greatest benefits in gaining strength, and endurance exercise did not.
CONCLUSIONS: PAE induced a significant decrease in strength compared to CTRL in PND21. Resistance exercise is the most effective to reverse the effects of PAE on muscular strength. Our data suggests that individualized, scheduled, and supervised training of resistance is more beneficial than endurance or enriched environment exercise for adolescents FASD.
摘要：
背景：产前酒精暴露（PAE）对儿童造成严重的身体后果，例如行为障碍，生长障碍,神经肌肉问题,运动协调受损，肌肉张力下降。然而,目前尚不清楚是否会出现肌肉力量的丧失，以及哪些干预措施将有效减轻物理PAE损伤。我们旨在调查青春期是否会持续改变身体，以及运动是否是有效的干预措施。
结果：使用范式评估不同的身体素质，我们描述了早期的PAE动物在敏捷性和力量上有显著的改变，与CTRL动物相比，平衡和协调没有改变。我们评估了3种不同运动方案的有效性，为期4周：浓缩环境（EE），耐力运动（EEX），和阻力运动（REX）。丰富的环境显着提高了PAE组的力量，但在即使在运动过程中也能保持力量参数的CTRL组中却没有。阻力运动在获得力量方面显示出最大的好处，耐力运动没有。
结论：在PND21中，与CTRL相比，PAE诱导强度显著降低。抗阻运动是逆转PAE对肌肉力量影响的最有效方法。我们的数据表明，个性化，scheduled,对于青少年FASD，有监督的阻力训练比耐力或丰富的环境锻炼更有益。
结果：使用范式评估不同的身体素质，我们描述了早期的PAE动物在敏捷性和力量上有显著的改变，与CTRL动物相比，平衡和协调没有改变。我们评估了3种不同运动方案的有效性，为期4周：浓缩环境（EE），耐力运动（EEX），和阻力运动（REX）。丰富的环境显着提高了PAE组的力量，但在即使在运动过程中也能保持力量参数的CTRL组中却没有。阻力运动在获得力量方面显示出最大的好处，耐力运动没有。
结论：在PND21中，与CTRL相比，PAE诱导强度显著降低。抗阻运动是逆转PAE对肌肉力量影响的最有效方法。我们的数据表明，个性化，scheduled,对于青少年FASD，有监督的阻力训练比耐力或丰富的环境锻炼更有益。
