Abstract：
OBJECTIVE: To describe the progression from outer retinal neovascularization (ORNV) to exudative subretinal new vessels (SRNVs) in idiopathic macular telangiectasia type 2.
METHODS: A total of 135 patients (270 eyes) imaged with optical coherence tomography angiography were included.
METHODS: Ellipsoid zone loss, outer retinal hyperreflectivity, ORNV, and SRNVs. Outer retinal neovascularization was defined as a flow signal passing through the outer plexiform layer, with or without vertical linear outer retinal hyperreflectivity on the optical coherence tomography B-scan. Subretinal new vessels were defined as an abnormal capillary network with a peripheral anastomotic arcade seen on en face optical coherence tomography angiography and a convex hyperreflectivity at the retinal pigment epithelium.
RESULTS: Subretinal new vessels were observed in 38/270 eyes (14%). Subretinal new vessels were at a fibrotic stage in 24/38 eyes and at an exudative stage in 6/38 eyes, and a progression from ORNV to SRNVs was documented in 8/38 eyes. All cases showed an ellipsoid zone loss. In seven eyes (2.5%), SRNVs were also associated with subepithelial neovascularization. No retinochoroidal anastomosis was detected. The visual acuity dropped when SRNVs were present.
CONCLUSIONS: In this case series, SRNVs were found in 14% of eyes. In all cases, they were associated with an ellipsoid zone loss and with outer retinal hyperreflectivity. A progression from ORNV to SRNVs was observed.
METHODS: A total of 135 patients (270 eyes) imaged with optical coherence tomography angiography were included.
METHODS: Ellipsoid zone loss, outer retinal hyperreflectivity, ORNV, and SRNVs. Outer retinal neovascularization was defined as a flow signal passing through the outer plexiform layer, with or without vertical linear outer retinal hyperreflectivity on the optical coherence tomography B-scan. Subretinal new vessels were defined as an abnormal capillary network with a peripheral anastomotic arcade seen on en face optical coherence tomography angiography and a convex hyperreflectivity at the retinal pigment epithelium.
RESULTS: Subretinal new vessels were observed in 38/270 eyes (14%). Subretinal new vessels were at a fibrotic stage in 24/38 eyes and at an exudative stage in 6/38 eyes, and a progression from ORNV to SRNVs was documented in 8/38 eyes. All cases showed an ellipsoid zone loss. In seven eyes (2.5%), SRNVs were also associated with subepithelial neovascularization. No retinochoroidal anastomosis was detected. The visual acuity dropped when SRNVs were present.
CONCLUSIONS: In this case series, SRNVs were found in 14% of eyes. In all cases, they were associated with an ellipsoid zone loss and with outer retinal hyperreflectivity. A progression from ORNV to SRNVs was observed.
摘要：
目的：描述2型特发性黄斑毛细血管扩张症从视网膜外新生血管（ORNV）到渗出性视网膜下新血管（SRRV）的进展。
方法：共纳入135例（270只眼）光学相干断层扫描血管造影成像患者。
方法：椭球区损失，外视网膜高反射率,ORNV,和SRRV。外视网膜新生血管被定义为通过外丛状层的血流信号，在光学相干断层扫描B扫描上有或没有垂直线性外视网膜高反射率。视网膜下新血管被定义为异常的毛细血管网络，在面部光学相干断层扫描血管造影术上看到周围吻合区域，并且在视网膜色素上皮上有凸起的高反射率。
结果：在38/270眼（14％）中观察到视网膜下新血管。视网膜下新血管在24/38眼中处于纤维化阶段，在6/38眼中处于渗出阶段，并且在8/38眼中记录了从ORNV到SRRNV的进展。所有病例均显示椭球区丢失。在七只眼睛（2.5％）中，SRRV也与上皮下新生血管形成有关。未检测到视网膜脉络膜吻合。当SRRV存在时，视敏度下降。
结论：在本案例系列中，在14%的眼睛中发现SRRV。在所有情况下,它们与椭圆体区丢失和外部视网膜高反射率有关。观察到从ORNV到SRRV的进展。
方法：共纳入135例（270只眼）光学相干断层扫描血管造影成像患者。
方法：椭球区损失，外视网膜高反射率,ORNV,和SRRV。外视网膜新生血管被定义为通过外丛状层的血流信号，在光学相干断层扫描B扫描上有或没有垂直线性外视网膜高反射率。视网膜下新血管被定义为异常的毛细血管网络，在面部光学相干断层扫描血管造影术上看到周围吻合区域，并且在视网膜色素上皮上有凸起的高反射率。
结果：在38/270眼（14％）中观察到视网膜下新血管。视网膜下新血管在24/38眼中处于纤维化阶段，在6/38眼中处于渗出阶段，并且在8/38眼中记录了从ORNV到SRRNV的进展。所有病例均显示椭球区丢失。在七只眼睛（2.5％）中，SRRV也与上皮下新生血管形成有关。未检测到视网膜脉络膜吻合。当SRRV存在时，视敏度下降。
结论：在本案例系列中，在14%的眼睛中发现SRRV。在所有情况下,它们与椭圆体区丢失和外部视网膜高反射率有关。观察到从ORNV到SRRV的进展。
