METHODS: A total of 135 patients (270 eyes) imaged with optical coherence tomography angiography were included.
METHODS: Ellipsoid zone loss, outer retinal hyperreflectivity, ORNV, and SRNVs. Outer retinal neovascularization was defined as a flow signal passing through the outer plexiform layer, with or without vertical linear outer retinal hyperreflectivity on the optical coherence tomography B-scan. Subretinal new vessels were defined as an abnormal capillary network with a peripheral anastomotic arcade seen on en face optical coherence tomography angiography and a convex hyperreflectivity at the retinal pigment epithelium.
RESULTS: Subretinal new vessels were observed in 38/270 eyes (14%). Subretinal new vessels were at a fibrotic stage in 24/38 eyes and at an exudative stage in 6/38 eyes, and a progression from ORNV to SRNVs was documented in 8/38 eyes. All cases showed an ellipsoid zone loss. In seven eyes (2.5%), SRNVs were also associated with subepithelial neovascularization. No retinochoroidal anastomosis was detected. The visual acuity dropped when SRNVs were present.
CONCLUSIONS: In this case series, SRNVs were found in 14% of eyes. In all cases, they were associated with an ellipsoid zone loss and with outer retinal hyperreflectivity. A progression from ORNV to SRNVs was observed.
方法:共纳入135例(270只眼)光学相干断层扫描血管造影成像患者。
方法:椭球区损失,外视网膜高反射率,ORNV,和SRRV。外视网膜新生血管被定义为通过外丛状层的血流信号,在光学相干断层扫描B扫描上有或没有垂直线性外视网膜高反射率。视网膜下新血管被定义为异常的毛细血管网络,在面部光学相干断层扫描血管造影术上看到周围吻合区域,并且在视网膜色素上皮上有凸起的高反射率。
结果:在38/270眼(14%)中观察到视网膜下新血管。视网膜下新血管在24/38眼中处于纤维化阶段,在6/38眼中处于渗出阶段,并且在8/38眼中记录了从ORNV到SRRNV的进展。所有病例均显示椭球区丢失。在七只眼睛(2.5%)中,SRRV也与上皮下新生血管形成有关。未检测到视网膜脉络膜吻合。当SRRV存在时,视敏度下降。
结论:在本案例系列中,在14%的眼睛中发现SRRV。在所有情况下,它们与椭圆体区丢失和外部视网膜高反射率有关。观察到从ORNV到SRRV的进展。