SOD1 是 PPM1D 突变白血病细胞中的合成致死靶标。
关键词: DNA damage cancer cancer biology cell biology leukemia mouse
Mesh : Protein Phosphatase 2C / metabolism genetics Humans Superoxide Dismutase-1 / genetics metabolism Cell Line, Tumor Leukemia / genetics CRISPR-Cas Systems Oxidative Stress Reactive Oxygen Species / metabolism Synthetic Lethal Mutations Mutation
来 源:
DOI:10.7554/eLife.91611
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