PDF(Pubmed)
Abstract：
Empathy enables understanding and sharing of others\' feelings. Human neuroimaging studies have identified critical brain regions supporting empathy for pain, including the anterior insula (AI), anterior cingulate (ACC), amygdala, and inferior frontal gyrus (IFG). However, to date, the precise spatio-temporal profiles of empathic neural responses and inter-regional communications remain elusive. Here, using intracranial electroencephalography, we investigated electrophysiological signatures of vicarious pain perception. Others\' pain perception induced early increases in high-gamma activity in IFG, beta power increases in ACC, but decreased beta power in AI and amygdala. Vicarious pain perception also altered the beta-band-coordinated coupling between ACC, AI, and amygdala, as well as increased modulation of IFG high-gamma amplitudes by beta phases of amygdala/AI/ACC. We identified a necessary combination of neural features for decoding vicarious pain perception. These spatio-temporally specific regional activities and inter-regional interactions within the empathy network suggest a neurodynamic model of human pain empathy.
摘要：
同理心能理解和分享他人的感受。人类神经影像学研究已经确定了支持同情疼痛的关键大脑区域，包括前岛（AI），前扣带(ACC),杏仁核,额下回（IFG）。然而,到目前为止,共情神经反应和区域间交流的精确时空分布仍然难以捉摸。这里,使用颅内脑电图，我们调查了替代疼痛感知的电生理特征。其他疼痛感知诱导IFG高γ活性早期增加，ACC中的β功率增加，但降低了AI和杏仁核的β能力。替代疼痛感知也改变了ACC之间的β带协调耦合，AI,和杏仁核,以及杏仁核/AI/ACC的β相增加对IFG高伽马振幅的调制。我们确定了用于解码替代疼痛感知的神经特征的必要组合。移情网络中这些时空特定的区域活动和区域间的相互作用提出了人类疼痛移情的神经动力学模型。
