Abstract：
Botulinum toxin A (BTX) and microwave thermolysis (MWT) are standard axillary hyperhidrosis treatments, but comparison of their subclinical effects is lacking. Line-field confocal optical coherence tomography (LC-OCT) is a promising non-invasive imaging tool for visualizing tissue-interactions. This study aimed to describe subclinical effects of BTX and MWT for axillary hyperhidrosis with LC-OCT-imaging compared to histology. This study derived from an intra-individual, randomized, controlled trial, treating axillary hyperhidrosis with BTX versus MWT. Subclinical effects based on LC-OCT images from baseline and 6-month follow-up (n = 8 patients) were evaluated and compared to corresponding histological samples. At baseline, LC-OCT visualized eccrine pores at the skin surface and ducts in the upper dermis (500 μm), but not deeper-lying sweat glands. Histology identified entire sweat glands. Six months post-treatment, LC-OCT revealed no detectable morphology changes in any BTX-treated axillae (100%), while recognizing obstructed eccrine pores and atrophy of eccrine ducts in most MWT-treated axillae (75%). Histology corroborated LC-OCT findings, while also showing substantial changes to entire sweat glands. LC-OCT enabled visualization of subclinical alterations of superficial eccrine ducts after MWT and unchanged morphology after BTX. LC-OCT is a promising tool for non-invasive assessment of treatment-specific tissue-interactions that can be complementary to histology.
摘要：
肉毒杆菌毒素A（BTX）和微波热解（MWT）是标准的腋窝多汗症治疗方法，但缺乏对亚临床效果的比较。线场共聚焦光学相干断层扫描（LC-OCT）是一种用于可视化组织相互作用的有前途的非侵入性成像工具。本研究旨在通过LC-OCT成像与组织学相比，描述BTX和MWT对腋窝多汗症的亚临床效果。这项研究来自个体内部，随机化，对照试验,BTX与MWT治疗腋窝多汗症。评估基于基线和6个月随访的LC-OCT图像的亚临床效果（n=8名患者），并与相应的组织学样本进行比较。在基线,LC-OCT显示皮肤表面和真皮上部导管的内分泌毛孔(500μm),但不是更深的汗腺.组织学鉴定了整个汗腺。治疗后六个月,LC-OCT显示在任何BTX处理的腋窝中没有可检测到的形态变化(100%),同时在大多数MWT治疗的腋窝（75％）中识别出阻塞的内分泌孔和内分泌管萎缩。组织学证实了LC-OCT的发现，同时也显示出整个汗腺的实质性变化。LC-OCT可以可视化MWT后浅表内分泌导管的亚临床改变和BTX后形态不变。LC-OCT是一种用于非侵入性评估治疗特异性组织相互作用的有前途的工具，可以补充组织学。
