背景:寻常痤疮(AV)是一种广泛的炎症性皮肤病,与皮脂产生增加有关,异常角质化,细菌过度生长,和炎症。过度活跃的皮脂腺(SGs)产生过多的皮脂,促进粉刺杆菌的生长,并影响痤疮的发展。基于能量的治疗(EBD),包括光疗,光动力疗法(PDT),激光,和射频(RF)设备,已成为有效的治疗选择。随着EBD的使用越来越广泛,必须了解它们对皮肤参数的影响,如皮脂,在AV。
方法:在Embase中进行搜索,PubMed,WebofScience,还有Cochrane图书馆.纳入的研究是关于面部房室的随机和非随机试验,这些试验使用了EBD,并通过Sebubometer进行了客观的休闲皮脂水平(CSL)测量。数据合成涉及与基线相比在随访时CSL的百分比降低。
结果:分析了23项研究。PDT和RF持续降低CSL30%-40%和30%-35%,分别。激光治疗显示减少较少,而光疗差异显著,研究存在较高的偏倚风险.所有EBD治疗都比不治疗更有效,PDT优于光单药治疗。激光治疗联合局部微针射频(FMR)或单独使用比单独使用激光更有效。
结论:非侵入性皮脂测量为AV治疗疗效提供了有价值的见解。PDT,激光,尤其是1450纳米二极管激光器,和FMR有望减少皮脂。测量技术的标准化和进一步的研究对于提高治疗个性化至关重要。减少副作用,改善AV管理。
BACKGROUND: Acne vulgaris (AV) is a widespread inflammatory skin condition associated with increased sebum production, abnormal keratinization, bacterial overgrowth, and inflammation. Overactive sebaceous glands (SGs) produce excess sebum, promote Cutibacterium acnes growth, and affect acne development. Energy-based treatments (EBDs), including light therapy, photodynamic therapy (PDT), lasers, and radiofrequency (RF) devices, have emerged as effective treatment options. As the use of EBDs becomes more widespread, it is imperative to understand their effects on skin parameters, such as sebum, in AV.
METHODS: Searches were conducted in Embase, PubMed, Web of Science, and the Cochrane Library. The studies included were randomized and nonrandomized trials on facial AV that used EBDs and featured objective casual sebum level (CSL) measurements via Sebumeter. Data synthesis involved percentage reductions in CSL at follow-ups compared to baseline.
RESULTS: Twenty-three studies were analyzed. PDT and RF consistently reduced CSL by 30%-40% and 30%-35%, respectively. Laser therapy showed lesser reductions, whereas light therapy varied significantly and studies had a high risk of bias. All EBD therapies were more effective than no treatment and PDT was superior to light monotherapy. Laser therapy combined with fractional microneedling radiofrequency (FMR) or as a standalone was more effective than laser alone.
CONCLUSIONS: Noninvasive sebum measurement provides valuable insights into AV treatment efficacy. PDT, lasers, especially the 1450-nm diode laser, and FMR are promising for reducing sebum. Standardization of measurement techniques and further research are vital for enhancing treatment personalization, reducing side effects, and improving AV management.