PDF(Pubmed)
Abstract：
Three-dimensional polymeric networks called hydrogels have drawn a lot of interest in a variety of biomedical applications because of their distinctive qualities, like high water content and biocompatibility. Hydrogels can be strengthened mechanically and become more stable via cross-linking. In this study, we described the synthesis and characterization of a cross-linked hydrogel made of polyethylene glycol (PEG) capable of absorbing drug. The hydrogel was created by using a polymerization procedure to cross-link PEG chains. In order to allay this worry, we added particular functional groups to the hydrogel matrix that had a strong affinity for glutaraldehyde. These functional groups made it easier for excess glutaraldehyde to be absorbed and sequestered inside the hydrogel, lowering its cytotoxic potential. After incubation with the hydrogel, the residual glutaraldehyde concentration in solution was measured in order to assess the glutaraldehyde absorption potential.
摘要：
称为水凝胶的三维聚合物网络由于其独特的特性而在各种生物医学应用中引起了极大的兴趣，如高含水量和生物相容性。水凝胶可以机械强化并通过交联变得更稳定。在这项研究中,我们描述了能够吸收药物的由聚乙二醇（PEG）制成的交联水凝胶的合成和表征。通过使用聚合程序交联PEG链产生水凝胶。为了减轻这种担忧，我们在对戊二醛具有强亲和力的水凝胶基质中加入了特定的官能团。这些官能团使得过量的戊二醛更容易在水凝胶中被吸收和隔离。降低其细胞毒性潜力。与水凝胶孵育后，测量溶液中残留的戊二醛浓度以评估戊二醛的吸收潜力。
