PDF(Pubmed)
Abstract：
BACKGROUND: Quantitative analysis of retinal nerve fibers is important for the diagnosis and treatment of optic nerve diseases. Peripapillary retinal nerve fiber layer (RNFL) cross-sectional area may give a more accurate quantitative assessment of retinal nerve fibers than RNFL thickness but there have been no previous reports of the peripapillary RNFL cross-sectional area or other parameters. The purpose of the current study was to determine peripapillary RNFL cross-sectional area and its association with other factors in an adult Chinese population.
METHODS: RNFL cross-sectional area was measured during peripapillary circular optical coherence tomography (OCT) scan with a diameter of 12° centered on the optic disc. Correlation between RNFL cross-sectional area and other parameters was evaluated by linear regression analysis in a cross-sectional study of an adult Chinese population.
RESULTS: A total of 2404 eyes from 2404 subjects were examined. Multivariate linear regression analysis showed that larger RNFL cross-sectional area correlated with younger age (p < 0.001), female gender (p = 0.001), no history of diabetes (p = 0.012) and larger optic disc area (p < 0.001).
CONCLUSIONS: Peripapillary RNFL cross-sectional area is correlated positively with optic disc area, suggesting that eyes with larger optic discs have thicker RNFL. Further studies are needed to confirm whether this correlation is due to differences in the numbers of retinal nerve fibers or other factors.
METHODS: RNFL cross-sectional area was measured during peripapillary circular optical coherence tomography (OCT) scan with a diameter of 12° centered on the optic disc. Correlation between RNFL cross-sectional area and other parameters was evaluated by linear regression analysis in a cross-sectional study of an adult Chinese population.
RESULTS: A total of 2404 eyes from 2404 subjects were examined. Multivariate linear regression analysis showed that larger RNFL cross-sectional area correlated with younger age (p < 0.001), female gender (p = 0.001), no history of diabetes (p = 0.012) and larger optic disc area (p < 0.001).
CONCLUSIONS: Peripapillary RNFL cross-sectional area is correlated positively with optic disc area, suggesting that eyes with larger optic discs have thicker RNFL. Further studies are needed to confirm whether this correlation is due to differences in the numbers of retinal nerve fibers or other factors.
摘要：
背景：视网膜神经纤维的定量分析对于视神经疾病的诊断和治疗具有重要意义。与RNFL厚度相比，乳头周围视网膜神经纤维层（RNFL）横截面积可以更准确地定量评估视网膜神经纤维，但以前没有关于乳头周围RNFL横截面积或其他参数的报道。本研究的目的是确定中国成年人群的乳头周围RNFL横截面积及其与其他因素的关系。
方法：在以视盘为中心的直径为12°的乳头周围圆形光学相干断层扫描（OCT）扫描过程中测量RNFL横截面积。在一项针对中国成年人口的横断面研究中，通过线性回归分析评估了RNFL横截面积与其他参数之间的相关性。
结果：共检查了2404名受试者的2404只眼。多元线性回归分析显示,RNFL横截面积大与年龄小相关(p<0.001),女性（p=0.001），无糖尿病史（p=0.012）和较大的视盘面积（p<0.001）。
结论：乳头周围RNFL横截面面积与视盘面积呈正相关，提示视盘较大的眼睛有较厚的RNFL。需要进一步的研究来确认这种相关性是否是由于视网膜神经纤维数量或其他因素的差异。
方法：在以视盘为中心的直径为12°的乳头周围圆形光学相干断层扫描（OCT）扫描过程中测量RNFL横截面积。在一项针对中国成年人口的横断面研究中，通过线性回归分析评估了RNFL横截面积与其他参数之间的相关性。
结果：共检查了2404名受试者的2404只眼。多元线性回归分析显示,RNFL横截面积大与年龄小相关(p<0.001),女性（p=0.001），无糖尿病史（p=0.012）和较大的视盘面积（p<0.001）。
结论：乳头周围RNFL横截面面积与视盘面积呈正相关，提示视盘较大的眼睛有较厚的RNFL。需要进一步的研究来确认这种相关性是否是由于视网膜神经纤维数量或其他因素的差异。
