PDF(Pubmed)
Abstract：
OBJECTIVE: The aim of this exploratory study is to investigate the role of S-cones in oscillatory potentials (OPs) generation by individuals with blue-cone monochromacy (BCM), retaining S-cones, and achromatopsia (ACHM), lacking cone functions.
METHODS: This retrospective study analyzed data from 39 ACHM patients, 20 BCM patients, and 26 controls. Central foveal thickness was obtained using spectral-domain optical coherence tomography, while amplitude and implicit time (IT) of a- and b-waves were extracted from the ISCEV Standard dark-adapted 3 cd.s.m-2 full-field ERG (ffERG). Time-frequency analysis of the same measurement enabled the extraction of OPs, providing insights into the dynamic characteristics of the recorded signal.
RESULTS: Both ACHM and BCM groups showed a significant reduction (p < .00001) of a- and b-wave amplitudes and ITs as well as the power of the OPs compared to the control groups. The comparison between ACHM and BCM didn\'t show any statistically significant differences in the electrophysiological parameters. The analysis of covariance revealed significantly reduced central foveal thickness in the BCM group compared to ACHM and controls (p < .00001), and in ACHM compared to controls (p < .00001), after age correction and Tukey post-hoc analysis.
CONCLUSIONS: S-cones do not significantly influence OPs, and the decline in OPs\' power is not solely due to a reduced a-wave. This suggests a complex non-linear network influenced by photoreceptor inputs. Morphological changes don\'t correlate directly with functional alterations, prompting further exploration of OPs\' function and physiological role.
METHODS: This retrospective study analyzed data from 39 ACHM patients, 20 BCM patients, and 26 controls. Central foveal thickness was obtained using spectral-domain optical coherence tomography, while amplitude and implicit time (IT) of a- and b-waves were extracted from the ISCEV Standard dark-adapted 3 cd.s.m-2 full-field ERG (ffERG). Time-frequency analysis of the same measurement enabled the extraction of OPs, providing insights into the dynamic characteristics of the recorded signal.
RESULTS: Both ACHM and BCM groups showed a significant reduction (p < .00001) of a- and b-wave amplitudes and ITs as well as the power of the OPs compared to the control groups. The comparison between ACHM and BCM didn\'t show any statistically significant differences in the electrophysiological parameters. The analysis of covariance revealed significantly reduced central foveal thickness in the BCM group compared to ACHM and controls (p < .00001), and in ACHM compared to controls (p < .00001), after age correction and Tukey post-hoc analysis.
CONCLUSIONS: S-cones do not significantly influence OPs, and the decline in OPs\' power is not solely due to a reduced a-wave. This suggests a complex non-linear network influenced by photoreceptor inputs. Morphological changes don\'t correlate directly with functional alterations, prompting further exploration of OPs\' function and physiological role.
摘要：
目的：这项探索性研究的目的是研究S锥在蓝锥单色（BCM）个体产生振荡电位（OP）中的作用，保留S-锥,和色盲（ACHM），缺乏圆锥功能。
方法：这项回顾性研究分析了39例ACHM患者的数据，20例BCM患者，26个控制中央凹厚度是使用光谱域光学相干断层扫描获得的，而a波和b波的振幅和隐含时间（IT）是从ISCEV标准暗适应的3cd.s.m-2全场ERG（ffERG）中提取的。对相同测量的时频分析可以提取OPs，提供对记录信号的动态特性的见解。
结果：与对照组相比，ACHM和BCM组均显示a-和b-波振幅和IT以及OP的功率显着降低（p<.00001）。ACHM和BCM之间的比较在电生理参数上没有显示任何统计学上的显着差异。协方差分析显示，与ACHM和对照组相比，BCM组的中央凹厚度显着降低（p<.00001），在ACHM中与对照组相比（p<.00001），经过年龄校正和Tukey事后分析。
结论：S-锥不显著影响OPs，OPs功率的下降不仅仅是由于a波的减少。这表明受感光器输入影响的复杂非线性网络。形态变化与功能改变不直接相关，促使人们进一步探索OPs的功能和生理作用。
方法：这项回顾性研究分析了39例ACHM患者的数据，20例BCM患者，26个控制中央凹厚度是使用光谱域光学相干断层扫描获得的，而a波和b波的振幅和隐含时间（IT）是从ISCEV标准暗适应的3cd.s.m-2全场ERG（ffERG）中提取的。对相同测量的时频分析可以提取OPs，提供对记录信号的动态特性的见解。
结果：与对照组相比，ACHM和BCM组均显示a-和b-波振幅和IT以及OP的功率显着降低（p<.00001）。ACHM和BCM之间的比较在电生理参数上没有显示任何统计学上的显着差异。协方差分析显示，与ACHM和对照组相比，BCM组的中央凹厚度显着降低（p<.00001），在ACHM中与对照组相比（p<.00001），经过年龄校正和Tukey事后分析。
结论：S-锥不显著影响OPs，OPs功率的下降不仅仅是由于a波的减少。这表明受感光器输入影响的复杂非线性网络。形态变化与功能改变不直接相关，促使人们进一步探索OPs的功能和生理作用。
