Abstract：
The integration of functional nanomaterials with tissue engineering scaffolds has emerged as a promising solution for simultaneously treating malignant bone tumors and repairing resected bone defects. However, achieving a uniform bioactive interface on 3D-printing polymer scaffolds with minimized microstructural heterogeneity remains a challenge. In this study, we report a facile metal-coordination self-assembly strategy for the surface engineering of 3D-printed polycaprolactone (PCL) scaffolds with nanostructured two-dimensional conjugated metal-organic frameworks (cMOFs) consisting of Cu ions and 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP). A tunable thickness of Cu-HHTP cMOF on PCL scaffolds was achieved via the alternative deposition of metal ions and HHTP. The resulting composite PCL@Cu-HHTP scaffolds not only demonstrated potent photothermal conversion capability for efficient OS ablation but also promoted the bone repair process by virtue of their cell-friendly hydrophilic interfaces. Therefore, the cMOF-engineered dual-functional 3D-printing scaffolds show promising potential for treating bone tumors by offering sequential anti-tumor effects and bone regeneration capabilities. This work also presents a new avenue for the interface engineering of bioactive scaffolds to meet multifaceted demands in osteosarcoma-related bone defects.
摘要：
功能性纳米材料与组织工程支架的整合已成为同时治疗恶性骨肿瘤和修复切除的骨缺损的有希望的解决方案。然而,在具有最小化的微结构异质性的3D打印聚合物支架上实现均匀的生物活性界面仍然是一个挑战。在这项研究中,我们报告了一种用于3D打印聚己内酯（PCL）支架的表面工程的简单金属配位自组装策略，该支架具有纳米结构的二维共轭金属有机框架（cMOF），该框架由Cu离子和2,3,6,7,10,11-六羟基三亚苯（HHTP）组成。通过金属离子和HHTP的交替沉积，可以在PCL支架上获得可调厚度的Cu-HHTPcMOF。所得的复合PCL@Cu-HHTP支架不仅表现出有效的OS消融的有效光热转化能力，而且由于其细胞友好的亲水界面而促进了骨修复过程。因此,cMOF设计的双功能3D打印支架通过提供连续的抗肿瘤作用和骨再生能力，显示出治疗骨肿瘤的有希望的潜力。这项工作还为生物活性支架的界面工程提供了一条新途径，以满足骨肉瘤相关骨缺损的多方面需求。
