■如何巧妙地设计多效光敏剂(PS),包括多模态成像和多通道治疗,对于高度时空可控的恶性肿瘤精确光疗具有重要意义。
■这里,一种新型的多功能锌(II)酞菁基平面微分子两亲物(ZnPc1)被成功地设计和合成,引入具有光致电子转移效应的N原子以增强近红外吸收和非辐射热的产生。在简单的自组装成纳米粒子(NPs)后,ZnPc1NP将表现出增强的多模态成像特性,包括荧光(FL)成像(FLI)/光声(PA)成像(PAI)/红外(IR)热成像,进一步用于指导联合光动力疗法(PDT)和光热疗法(PTT)。
■在多模态成像的自我指导下,ZnPc1NP可以从垂直和水平边界精确地确定肿瘤,从而实现高效和准确的癌症治疗。
■因此,将FL/PA/IR多模式成像和PDT/PTT协同治疗途径整合到一个ZnPc1中,可以为下一代光疗提供蓝图,这为肿瘤诊断和治疗的整合提供了新的范式,并为精确的癌症治疗提供了有希望的前景。
UNASSIGNED: How to ingeniously design multi-effect photosensitizers (PSs), including multimodal imaging and multi-channel therapy, is of great significance for highly spatiotemporal controllable precise phototherapy of malignant tumors.
UNASSIGNED: Herein, a novel multifunctional zinc(II) phthalocyanine-based planar micromolecule amphiphile (ZnPc 1) was successfully designed and synthesized, in which N atom with photoinduced electron transfer effect was introduced to enhance the near-infrared absorbance and nonradiative heat generation. After simple self-assembling into nanoparticles (NPs), ZnPc 1 NPs would exhibit enhanced multimodal imaging properties including fluorescence (FL) imaging (FLI) /photoacoustic (PA) imaging (PAI) /infrared (IR) thermal imaging, which was further used to guide the combined photodynamic therapy (PDT) and photothermal therapy (PTT).
UNASSIGNED: It was that under the self-guidance of the multimodal imaging, ZnPc 1 NPs could precisely pinpoint the tumor from the vertical and horizontal boundaries achieving highly efficient and accurate treatment of cancer.
UNASSIGNED: Accordingly, the integration of FL/PA/IR multimodal imaging and PDT/PTT synergistic therapy pathway into one ZnPc 1 could provide a blueprint for the next generation of phototherapy, which offered a new paradigm for the integration of diagnosis and treatment in tumor and a promising prospect for precise cancer therapy.