Abstract：
BACKGROUND: The coronavirus disease 2019 (COVID-19) spread rapidly in Shanghai in February 2022. Patients with asymptomatic and mild symptoms were admitted to Fangcang shelter hospitals for centralized quarantine.
METHODS: A total of 5,217 non-severe patients hospitalized in the Longyao Fangcang and Shilong Fangcang hospitals were included in the study. Demographic and clinical characteristics, comorbidity, exposure history, treatment and disease duration were analyzed. Univariate analysis and binomial logistic regression analysis were performed to identify the factors influencing nucleic acid change from positive to negative over 14 days.
RESULTS: Consecutive positive nucleic acid test results (days) were significantly associated with advanced age (OR = 1.343, 95% CI 1.143 to 1.578, p < 0.001), smoking (OR = 0.510, 95% CI 0.327 to 0.796, p = 0.003) and vaccination (OR = 0.728, 95% CI 0.641 to 0.827, p < 0.001). However, there was no significant difference between asymptomatic and mild symptomatic patients (p = 0.187). In univariate analysis, comorbidities including diabetes, hypertension, cardiovascular system, malignant tumors, autoimmune diseases and cerebral apoplexy were associated with consecutive positive nucleic acid test results, but there was no significant difference in binomial logistics regression analysis.
CONCLUSIONS: Aging and comorbid conditions lead to the prolongation of positive nucleic acid test results for several days. Improving vaccination coverage is beneficial for prevention and control of the epidemic. The management and treatment methods of Shanghai Fangcang shelter hospitals had important referential significance, which can provide valuable guidance for the prevention and control of the COVID-19 epidemic in the future.
METHODS: A total of 5,217 non-severe patients hospitalized in the Longyao Fangcang and Shilong Fangcang hospitals were included in the study. Demographic and clinical characteristics, comorbidity, exposure history, treatment and disease duration were analyzed. Univariate analysis and binomial logistic regression analysis were performed to identify the factors influencing nucleic acid change from positive to negative over 14 days.
RESULTS: Consecutive positive nucleic acid test results (days) were significantly associated with advanced age (OR = 1.343, 95% CI 1.143 to 1.578, p < 0.001), smoking (OR = 0.510, 95% CI 0.327 to 0.796, p = 0.003) and vaccination (OR = 0.728, 95% CI 0.641 to 0.827, p < 0.001). However, there was no significant difference between asymptomatic and mild symptomatic patients (p = 0.187). In univariate analysis, comorbidities including diabetes, hypertension, cardiovascular system, malignant tumors, autoimmune diseases and cerebral apoplexy were associated with consecutive positive nucleic acid test results, but there was no significant difference in binomial logistics regression analysis.
CONCLUSIONS: Aging and comorbid conditions lead to the prolongation of positive nucleic acid test results for several days. Improving vaccination coverage is beneficial for prevention and control of the epidemic. The management and treatment methods of Shanghai Fangcang shelter hospitals had important referential significance, which can provide valuable guidance for the prevention and control of the COVID-19 epidemic in the future.
摘要：
背景：冠状病毒病2019（COVID-19）于2022年2月在上海迅速传播。无症状和轻度症状的患者被送往方仓庇护所医院进行集中隔离。
方法：纳入隆耀方仓和石龙方仓医院住院的非重症患者5217例。人口统计学和临床特征，合并症，曝光历史，治疗和病程分析。进行单变量分析和二项逻辑回归分析以确定影响14天内核酸从阳性到阴性变化的因素。
结果：连续核酸检测结果（天数）与高龄显着相关（OR=1.343，95％CI1.143至1.578，p<0.001），吸烟(OR=0.510，95%CI0.327至0.796，p=0.003)和疫苗接种(OR=0.728，95%CI0.641至0.827，p<0.001)。然而,无症状和轻度症状患者之间无显著差异(p=0.187).在单变量分析中，包括糖尿病在内的合并症，高血压,心血管系统,恶性肿瘤,自身免疫性疾病和脑卒中与核酸检测结果连续阳性有关，但二项物流回归分析无显著差异。
结论：老化和合并症导致阳性核酸检测结果延长数天。提高疫苗接种覆盖率有利于预防和控制疫情。上海方仓庇护所医院的管理和处理方法具有重要的借鉴意义，可为今后COVID-19疫情的防控提供有价值的指导。
方法：纳入隆耀方仓和石龙方仓医院住院的非重症患者5217例。人口统计学和临床特征，合并症，曝光历史，治疗和病程分析。进行单变量分析和二项逻辑回归分析以确定影响14天内核酸从阳性到阴性变化的因素。
结果：连续核酸检测结果（天数）与高龄显着相关（OR=1.343，95％CI1.143至1.578，p<0.001），吸烟(OR=0.510，95%CI0.327至0.796，p=0.003)和疫苗接种(OR=0.728，95%CI0.641至0.827，p<0.001)。然而,无症状和轻度症状患者之间无显著差异(p=0.187).在单变量分析中，包括糖尿病在内的合并症，高血压,心血管系统,恶性肿瘤,自身免疫性疾病和脑卒中与核酸检测结果连续阳性有关，但二项物流回归分析无显著差异。
结论：老化和合并症导致阳性核酸检测结果延长数天。提高疫苗接种覆盖率有利于预防和控制疫情。上海方仓庇护所医院的管理和处理方法具有重要的借鉴意义，可为今后COVID-19疫情的防控提供有价值的指导。
