PDF(Pubmed)
Abstract：
This study aims to investigate the structural reorganization in the sensorimotor area of the brain in patients with gliomas, distinguishing between those with impaired and unimpaired strength. Using voxel-based morphometry (VBM) and region of interest (ROI) analysis, gray matter volumes (GMV) were compared in the contralesional primary motor gyrus, primary sensory gyrus, premotor area, bilateral supplementary motor area, and medial Brodmann area 8 (BA8). The results revealed that in patients with right hemisphere gliomas, the right medial BA8 volume was significantly larger in the impaired group than in the unimpaired group, with both groups exceeding the volume in 16 healthy controls (HCs). In patients with left hemisphere gliomas, the right supplementary motor area (SMA) was more pronounced in the impaired group compared to the unimpaired group, and both groups were greater than HCs. Additionally, the volumes of the right medial BA8 in both the impaired group were greater than HCs. Contralateral expansions in the gray matter of hand- and trunk-related cortices of the premotor area, precentral gyrus, and postcentral gyrus were observed compared to HCs. Furthermore, a negative correlation was found between hand Medical Research Council (MRC) score and volumes of the contralateral SMA and bilateral medial BA8. Notably, our findings reveal consistent results across both analytical approaches in identifying significant structural reorganizations within the sensorimotor cortex. These consistent findings underscore the adaptive neuroplastic responses to glioma presence, highlighting potential areas of interest for further neurosurgical planning and rehabilitation strategies.
摘要：
本研究旨在研究胶质瘤患者大脑感觉运动区域的结构重组，区分那些受损和未受损的力量。使用基于体素的形态测量(VBM)和感兴趣区域(ROI)分析，比较了主运动回的灰质体积（GMV），初级感觉回,电机前区域,双侧辅助电机区，和内侧Brodmann区域8（BA8）。结果显示，在右半球胶质瘤患者中，受损组的右侧内侧BA8体积明显大于未受损组，两组均超过16个健康对照（HCs）的体积。在左半球胶质瘤患者中，与未受损组相比，受损组的右辅助运动区（SMA）更为明显，两组均大于HCs。此外,两个受损组的右侧内侧BA8体积均大于HC.运动前区域的手和躯干相关皮质的灰质对侧扩张，中央前回,与HCs相比，观察到中央后回。此外，在手医学研究理事会(MRC)评分与对侧SMA和双侧内侧BA8体积之间呈负相关.值得注意的是,我们的研究结果揭示了两种分析方法在确定感觉运动皮层内显著的结构重组方面的一致结果.这些一致的发现强调了神经胶质瘤存在的适应性神经可塑性反应，强调进一步神经外科计划和康复策略的潜在兴趣领域。
