Abstract：
Nodding syndrome is an epileptic encephalopathy associated with neuroinflammation and tauopathy. This initially pediatric brain disease, which has some clinical overlap with Methyl-CpG-binding protein 2 (MECP2) Duplication Syndrome, has impacted certain impoverished East African communities coincident with local civil conflict and internal displacement, conditions that forced dependence on contaminated food and water. A potential role in Nodding syndrome for certain biotoxins (freshwater cyanotoxins plus/minus mycotoxins) with neuroinflammatory, excitotoxic, tauopathic, and MECP2-dysregulating properties, is considered here for the first time.
摘要：
Nodding综合征是一种与神经炎症和tau蛋白病相关的癫痫性脑病。最初是小儿脑部疾病，与甲基-CpG结合蛋白2（MECP2）重复综合征有一些临床重叠，影响了某些贫困的东非社区，同时发生了当地的内战和国内流离失所，迫使人们依赖受污染的食物和水的条件。某些生物毒素（淡水蓝藻毒素加/减霉菌毒素）与神经炎症在Nodding综合征中的潜在作用，兴奋毒性，Tau病法,和MECP2失调特性，在这里是第一次考虑。
