{Reference Type}: Journal Article
{Title}: Nodding syndrome: A role for environmental biotoxins that dysregulate MECP2 expression?
{Author}: Spencer PS;Valdes Angues R;Palmer VS;
{Journal}: J Neurol Sci
{Volume}: 462
{Issue}: 0
{Year}: 2024 Jul 15
{Factor}: 4.553
{DOI}: 10.1016/j.jns.2024.123077
{Abstract}: Nodding syndrome is an epileptic encephalopathy associated with neuroinflammation and tauopathy. This initially pediatric brain disease, which has some clinical overlap with Methyl-CpG-binding protein 2 (MECP2) Duplication Syndrome, has impacted certain impoverished East African communities coincident with local civil conflict and internal displacement, conditions that forced dependence on contaminated food and water. A potential role in Nodding syndrome for certain biotoxins (freshwater cyanotoxins plus/minus mycotoxins) with neuroinflammatory, excitotoxic, tauopathic, and MECP2-dysregulating properties, is considered here for the first time.