Abstract：
Biliary dysbiosis is associated with gallbladder cancer (GBC). We aimed to look for biliary bacteria specifically detected in GBC patients. We used 16S rRNA-based metagenomic analysis to elucidate biliary microbiota in 30 GBC and 30 gallstones-associated chronic cholecystitis patients. Relative abundance of five genera, Streptococcus, Enterococcus, Halomonas, Escherichia and Caulobacter was significantly associated with GBC. Of 15-species, 7 were detected significantly higher in GBC, Streptococcus anginosus, Streptococcus constellatus, Streptococcus intermedius, Actinomyces bowdenii, Actinomyces israelii, Actinomyces gerencseriae, and Escherichia fergusonii were biosafety level-2 infectious bacteria; other 8 species were biosafety level-1 bacteria. These bacterial species may be involved in pathogenesis of GBC.
摘要：
胆道菌群失调与胆囊癌（GBC）有关。我们旨在寻找在GBC患者中特异性检测到的胆道细菌。我们使用基于16SrRNA的宏基因组分析来阐明30个GBC和30个胆结石相关的慢性胆囊炎患者的胆道微生物群。五个属的相对丰度，链球菌,肠球菌,Halomonas,大肠埃希氏菌和枯草杆菌与GBC显著相关。15种，7在GBC中检测到显著较高，硬化链球菌,星座链球菌,中间链球菌,鲍德尼放线菌，放线菌以色列，放线菌，和大肠杆菌为生物安全2级感染细菌；其他8种为生物安全1级细菌。这些细菌可能与GBC的发病机理有关。
