PDF(Pubmed)
Abstract：
Drosophila nervous system development progresses through a series of well-characterized steps in which homeodomain transcription factors (HDTFs) play key roles during most, if not all, phases. Strikingly, although some HDTFs have only one role, many others are involved in multiple steps of the developmental process. Most Drosophila HDTFs engaged in nervous system development are conserved in vertebrates and often play similar roles during vertebrate development. In this Spotlight, we focus on the role of HDTFs during embryogenesis, where they were first characterized.
摘要：
果蝇神经系统发育通过一系列特征明确的步骤进行，其中同源结构域转录因子（HDTFs）在大多数过程中发挥关键作用，如果不是全部,阶段。引人注目的是，虽然一些HDTF只有一个角色，许多其他人参与了发展过程的多个步骤。大多数参与神经系统发育的果蝇HDTF在脊椎动物中都是保守的，并且在脊椎动物发育过程中经常发挥类似的作用。在这个聚光灯下，我们关注HDTFs在胚胎发育过程中的作用，他们最初被描述的地方。
