Abstract：
Hyaluronic acid-based hydrogels have been broadly used in medical applications due to their remarkable properties such as biocompatibility, biodegradability, super hydroscopicity, non-immunogenic effect, etc. However, the inherent weak and hydrophilic polysaccharide structure of pure hyaluronic acid (HA) hydrogels has limited their potential use in muco-adhesiveness, wound dressing, and 3D printing. In this research, we developed in-situ forming of catechol-modified HA hydrogels with improved mechanical properties involving blue-light curing crosslinking reaction. The effect of catechol structure on the physicochemical properties of HA hydrogels was evaluated by varying the content (0-40 %). The as-synthesized hydrogel demonstrated rapid prototyping, excellent wetting adhesiveness, and good biocompatibility. Furthermore, an optimized hydrogel precursor solution was used as a blue light-cured bio-ink with high efficiency and good precision and successfully prototyped a microstructure that mimicked the human hepatic lobule by using DLP 3D printing method. This catechol-modified HA hydrogel with tunable physicochemical and rapid prototyping properties has excellent potential in biomedical engineering.
摘要：
基于透明质酸的水凝胶由于其显著的性能，如生物相容性，已广泛用于医疗应用。生物降解性，超吸水性,非免疫原性作用，等。然而,纯透明质酸（HA）水凝胶固有的弱和亲水性多糖结构限制了它们在粘膜粘附性方面的潜在用途，伤口敷料,3D打印。在这项研究中,我们开发了原位形成邻苯二酚改性的HA水凝胶，具有改善的机械性能，涉及蓝光固化交联反应。通过改变含量（0-40％）来评估邻苯二酚结构对HA水凝胶理化性质的影响。合成的水凝胶证明了快速成型，优异的润湿粘合性，和良好的生物相容性。此外，一种优化的水凝胶前体溶液被用作具有高效率和良好精度的蓝光固化生物墨水，并通过使用DLP3D打印方法成功地原型模拟了人类肝小叶的微观结构。这种邻苯二酚修饰的HA水凝胶具有可调的物理化学和快速成型性能，在生物医学工程中具有出色的潜力。
