%0 Journal Article
%T Tunable and fast-cured hyaluronic acid hydrogel inspired on catechol architecture for enhanced adhesion property.
%A Yang F
%A Chen Y
%A Zhang W
%A Gu S
%A Liu Z
%A Chen M
%A Chen L
%A Chen F
%A Zhang H
%A Ding Y
%A Liu Y
%A Chen J
%A Wang L
%J Int J Biol Macromol
%V 271
%N 0
%D 2024 Jun 8
%M 38816297
%F 8.025
%R 10.1016/j.ijbiomac.2024.132119
%X Hyaluronic acid-based hydrogels have been broadly used in medical applications due to their remarkable properties such as biocompatibility, biodegradability, super hydroscopicity, non-immunogenic effect, etc. However, the inherent weak and hydrophilic polysaccharide structure of pure hyaluronic acid (HA) hydrogels has limited their potential use in muco-adhesiveness, wound dressing, and 3D printing. In this research, we developed in-situ forming of catechol-modified HA hydrogels with improved mechanical properties involving blue-light curing crosslinking reaction. The effect of catechol structure on the physicochemical properties of HA hydrogels was evaluated by varying the content (0-40 %). The as-synthesized hydrogel demonstrated rapid prototyping, excellent wetting adhesiveness, and good biocompatibility. Furthermore, an optimized hydrogel precursor solution was used as a blue light-cured bio-ink with high efficiency and good precision and successfully prototyped a microstructure that mimicked the human hepatic lobule by using DLP 3D printing method. This catechol-modified HA hydrogel with tunable physicochemical and rapid prototyping properties has excellent potential in biomedical engineering.