{Reference Type}: Journal Article
{Title}: Tunable and fast-cured hyaluronic acid hydrogel inspired on catechol architecture for enhanced adhesion property.
{Author}: Yang F;Chen Y;Zhang W;Gu S;Liu Z;Chen M;Chen L;Chen F;Zhang H;Ding Y;Liu Y;Chen J;Wang L;
{Journal}: Int J Biol Macromol
{Volume}: 271
{Issue}: 0
{Year}: 2024 Jun 8
{Factor}: 8.025
{DOI}: 10.1016/j.ijbiomac.2024.132119
{Abstract}: Hyaluronic acid-based hydrogels have been broadly used in medical applications due to their remarkable properties such as biocompatibility, biodegradability, super hydroscopicity, non-immunogenic effect, etc. However, the inherent weak and hydrophilic polysaccharide structure of pure hyaluronic acid (HA) hydrogels has limited their potential use in muco-adhesiveness, wound dressing, and 3D printing. In this research, we developed in-situ forming of catechol-modified HA hydrogels with improved mechanical properties involving blue-light curing crosslinking reaction. The effect of catechol structure on the physicochemical properties of HA hydrogels was evaluated by varying the content (0-40 %). The as-synthesized hydrogel demonstrated rapid prototyping, excellent wetting adhesiveness, and good biocompatibility. Furthermore, an optimized hydrogel precursor solution was used as a blue light-cured bio-ink with high efficiency and good precision and successfully prototyped a microstructure that mimicked the human hepatic lobule by using DLP 3D printing method. This catechol-modified HA hydrogel with tunable physicochemical and rapid prototyping properties has excellent potential in biomedical engineering.