PDF(Pubmed)
Abstract：
Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high proportion of co-morbidities. Hence, research is constantly looking for novel, effective molecules to treat CVD and T2DM with minimal side effects. Marine active compounds, holding a great diversity of chemical structures and biological properties, represent interesting therapeutic candidates to treat these age-related diseases. This review summarizes the current state of research on marine compounds for the treatment of CVD and T2DM, from pre-clinical studies to clinical investigations and approved drugs, highlighting the potential of marine compounds in the development of new therapies, together with the limitations in translating pre-clinical results into human application.
摘要：
衰老是几种疾病的主要危险因素。其中,心血管疾病(CVD)和2型糖尿病(T2DM)在老年人群中占主导地位,并且由于其慢性性质和高比例的合并症,通常需要长期使用多种药物.因此，研究一直在寻找小说，有效分子治疗CVD和T2DM，副作用最小。海洋活性化合物，拥有丰富多样的化学结构和生物学特性，代表治疗这些与年龄有关的疾病的有趣的治疗候选人。本文综述了海洋化合物治疗CVD和T2DM的研究现状。从临床前研究到临床研究和批准的药物，强调海洋化合物在开发新疗法方面的潜力，以及将临床前结果转化为人类应用的局限性。
