PDF(Pubmed)
Abstract：
Repetitive transcranial magnetic stimulation (rTMS) for alleviating negative symptoms and cognitive dysfunction in schizophrenia commonly targets the left dorsolateral prefrontal cortex (LDLPFC). However, the therapeutic effectiveness of rTMS at this site remains inconclusive and increasingly, studies are focusing on cerebellar rTMS. Recently, prolonged intermittent theta-burst stimulation (iTBS) has emerged as a rapid-acting form of rTMS with promising clinical benefits. This study explored the cognitive and neurophysiological effects of prolonged iTBS administered to the LDLPFC and cerebellum in a healthy cohort. 50 healthy participants took part in a cross-over study and received prolonged (1800 pulses) iTBS targeting the LDLPFC, cerebellar vermis, and sham iTBS. Mixed effects repeated measures models examined cognitive and event-related potentials (ERPs) from 2-back (P300, N200) and Stroop (N200, N450) tasks after stimulation. Exploratory non-parametric cluster-based permutation tests compared ERPs between conditions. There were no significant differences between conditions for behavioural and ERP outcomes on the 2-back and Stroop tasks. Exploratory cluster-based permutation tests of ERPs did not identify any significant differences between conditions. We did not find evidence that a single session of prolonged iTBS administered to either the LDLPFC or cerebellum could cause any cognitive or ERP changes compared to sham in a healthy sample.
摘要：
用于缓解精神分裂症阴性症状和认知功能障碍的重复经颅磁刺激（rTMS）通常靶向左背外侧前额叶皮质（LDLPFC）。然而,rTMS在这个部位的治疗效果仍然没有定论，而且越来越多，研究集中在小脑rTMS上。最近,长时间间歇性theta爆发刺激(iTBS)已成为rTMS的一种快速起效形式,具有良好的临床获益.这项研究探索了在健康队列中对LDLPFC和小脑施用延长iTBS的认知和神经生理作用。50名健康参与者参加了一项交叉研究，并接受了针对LDLPFC的长时间（1800个脉冲）iTBS，小脑疣,和假iTBS。混合效应重复测量模型检查了刺激后2回（P300，N200）和Stroop（N200，N450）任务的认知和事件相关电位（ERP）。探索性非参数基于聚类的置换检验比较了条件之间的ERP。2-back和Stroop任务的行为和ERP结果条件之间没有显着差异。ERPs的基于聚类的探索性置换检验未发现条件之间的任何显着差异。我们没有发现证据表明，与健康样本中的假手术相比，对LDLPFC或小脑进行一次长时间的iTBS可能会导致任何认知或ERP变化。
