PDF(Pubmed)
Abstract：
Scedosporium spp. and Lomentospora prolificans are emerging non-Aspergillus filamentous fungi. The Scedosporiosis/lomentosporiosis Observational Study we previously conducted reported frequent fungal vascular involvement, including aortitis and peripheral arteritis. For this article, we reviewed 7 cases of Scedosporium spp. and L. prolificans arteritis from the Scedosporiosis/lomentosporiosis Observational Study and 13 cases from published literature. Underlying immunosuppression was reported in 70% (14/20) of case-patients, mainly those who had solid organ transplants (10/14). Osteoarticular localization of infection was observed in 50% (10/20) of cases; infections were frequently (7/10) contiguous with vascular infection sites. Scedosporium spp./Lomentospora prolificans infections were diagnosed in 9 of 20 patients ≈3 months after completing treatment for nonvascular scedosporiosis/lomentosporiosis. Aneurysms were found in 8/11 aortitis and 6/10 peripheral arteritis cases. Invasive fungal disease--related deaths were high (12/18 [67%]). The vascular tropism of Scedosporium spp. and L. prolificans indicates vascular imaging, such as computed tomography angiography, is needed to manage infections, especially for osteoarticular locations.
摘要：
Scedosporiumspp.和长龙孢菌是新兴的非曲霉丝状真菌。我们以前进行的Scedosporiosis/lomentosporiosis观察性研究报告了频繁的真菌血管受累，包括主动脉炎和外周动脉炎。对于这篇文章，我们回顾了7例Scedosporiumspp。和产乳杆菌性动脉炎来自头孢孢子菌病/lomentosporiosis观察研究和13例来自已发表文献。据报道，70%(14/20)的病例患者存在潜在的免疫抑制，主要是那些有实体器官移植（10/14）。在50％（10/20）的病例中观察到骨关节感染的定位；感染经常（7/10）与血管感染部位相邻。Scedosporiumspp./20例患者中有9例在完成非血管性scedosporiosis/lomentosporiosis治疗后3个月内被诊断出感染。在8/11主动脉炎和6/10周围动脉炎病例中发现动脉瘤。侵袭性真菌疾病相关死亡人数较高（12/18[67%]）。头孢孢子菌属的血管嗜性。产乳杆菌显示血管成像，比如计算机断层扫描血管造影，需要管理感染，特别是对于骨关节位置。
