{Reference Type}: Journal Article
{Title}: Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France.
{Author}: Vignals C;Emmerich J;Begueret H;Garcia-Hermoso D;Martin-Blondel G;Angoulvant A;Blez D;Bruneval P;Cassaing S;Catherinot E;Cahen P;Moluçon-Chabrot C;Chevenet C;Delhaes L;Escaut L;Faruch M;Grenouillet F;Larosa F;Limousin L;Longchampt E;Mellot F;Nourrisson C;Bougnoux ME;Lortholary O;Roux A;Rozenblum L;Puges M;Lanternier F;Bronnimann D;
{Journal}: Emerg Infect Dis
{Volume}: 30
{Issue}: 6
{Year}: 2024 Jun
{Factor}: 16.126
{DOI}: 10.3201/eid3006.231409
{Abstract}: Scedosporium spp. and Lomentospora prolificans are emerging non-Aspergillus filamentous fungi. The Scedosporiosis/lomentosporiosis Observational Study we previously conducted reported frequent fungal vascular involvement, including aortitis and peripheral arteritis. For this article, we reviewed 7 cases of Scedosporium spp. and L. prolificans arteritis from the Scedosporiosis/lomentosporiosis Observational Study and 13 cases from published literature. Underlying immunosuppression was reported in 70% (14/20) of case-patients, mainly those who had solid organ transplants (10/14). Osteoarticular localization of infection was observed in 50% (10/20) of cases; infections were frequently (7/10) contiguous with vascular infection sites. Scedosporium spp./Lomentospora prolificans infections were diagnosed in 9 of 20 patients ≈3 months after completing treatment for nonvascular scedosporiosis/lomentosporiosis. Aneurysms were found in 8/11 aortitis and 6/10 peripheral arteritis cases. Invasive fungal disease--related deaths were high (12/18 [67%]). The vascular tropism of Scedosporium spp. and L. prolificans indicates vascular imaging, such as computed tomography angiography, is needed to manage infections, especially for osteoarticular locations.