Abstract：
UNASSIGNED: Potentially inappropriate medication (PIM) use is a common problem among older patients. This study aimed to compare the prevalence of PIMs in older patients with newly diagnosed non-small cell lung cancer (NSCLC), and to identify the correlates of PIMs.
UNASSIGNED: A secondary analysis of a prospective cohort study was conducted. Patients were enrolled from January 2014 to December 2020 and information were extracted from patients\' electronic medical records (EMRs). We evaluated the PIMs using four different PIM criteria. The concordance among the four PIM criteria was calculated using kappa tests. The possible risk factors associated with PIMs were analyzed by multivariate logistic regression.
UNASSIGNED: The prevalence of at least one PIM identified by the four criteria ranged from 25.1% to 48.2% among 514 patients. There was moderate consistency between the GO-PIM scale and the AGS/Beers criteria, while poor consistency with the other criteria (the STOPP criteria and the Chinese criteria). Polypharmacy was found to be significantly associated with the occurrence of PIMs in all criteria (p < 0.001).
UNASSIGNED: Our results showed a high prevalence of PIMs in older patients with NSCLC, which was significantly associated with polypharmacy, and the consistency across the four criteria was poor-to-moderate.
UNASSIGNED: A secondary analysis of a prospective cohort study was conducted. Patients were enrolled from January 2014 to December 2020 and information were extracted from patients\' electronic medical records (EMRs). We evaluated the PIMs using four different PIM criteria. The concordance among the four PIM criteria was calculated using kappa tests. The possible risk factors associated with PIMs were analyzed by multivariate logistic regression.
UNASSIGNED: The prevalence of at least one PIM identified by the four criteria ranged from 25.1% to 48.2% among 514 patients. There was moderate consistency between the GO-PIM scale and the AGS/Beers criteria, while poor consistency with the other criteria (the STOPP criteria and the Chinese criteria). Polypharmacy was found to be significantly associated with the occurrence of PIMs in all criteria (p < 0.001).
UNASSIGNED: Our results showed a high prevalence of PIMs in older patients with NSCLC, which was significantly associated with polypharmacy, and the consistency across the four criteria was poor-to-moderate.
摘要：
■可能不适当的药物（PIM）使用是老年患者的常见问题。这项研究旨在比较新诊断的非小细胞肺癌（NSCLC）的老年患者中PIMs的患病率。并确定PIM的相关性。
■对前瞻性队列研究进行了二次分析。从2014年1月至2020年12月招募患者，并从患者的电子病历（EMR）中提取信息。我们使用四种不同的PIM标准评估了PIM。使用kappa检验计算四个PIM标准之间的一致性。采用多因素logistic回归分析与PIMs相关的可能危险因素。
■在514名患者中，由四个标准确定的至少一种PIM的患病率范围为25.1％至48.2％。GO-PIM量表与AGS/Beers标准之间存在中度一致性，而与其他标准(STOPP标准和中国标准)的一致性较差。在所有标准中发现多重用药与PIM的发生显著相关(p<0.001)。
■我们的结果显示，老年非小细胞肺癌患者中PIMs的患病率很高，这与多重用药密切相关，四项标准的一致性从低到中等。
■对前瞻性队列研究进行了二次分析。从2014年1月至2020年12月招募患者，并从患者的电子病历（EMR）中提取信息。我们使用四种不同的PIM标准评估了PIM。使用kappa检验计算四个PIM标准之间的一致性。采用多因素logistic回归分析与PIMs相关的可能危险因素。
■在514名患者中，由四个标准确定的至少一种PIM的患病率范围为25.1％至48.2％。GO-PIM量表与AGS/Beers标准之间存在中度一致性，而与其他标准(STOPP标准和中国标准)的一致性较差。在所有标准中发现多重用药与PIM的发生显著相关(p<0.001)。
■我们的结果显示，老年非小细胞肺癌患者中PIMs的患病率很高，这与多重用药密切相关，四项标准的一致性从低到中等。
