Abstract：
A growing body of evidence suggests that elevated sucrose intake may contribute to the development of neurological disorders. Recognizing that regular exercise has the potential to reduce the occurrence of neuromuscular disorders, the present research investigated the impact of exercise on the redox status of the hypothalamus in mitigating the adverse effects associated with high sucrose intake. Forty Wistar albino rats were subjected to a high sucrose diet, with some groups engaging in exercise for a duration of 3 months. The exercise regimen was found to sustain the redox balance in the hypothalamus. In summary, the consumption of a high sucrose diet resulted in the disturbance of the histological morphology of the hypothalamus, accompanied by an increased percentage of caspase-3 positive cells. Additionally, the high sucrose diet disrupted the oxidant/antioxidant ratio in favor of oxidants, leading to elevated levels of AOPPs and AGEP. Conversely, exercise was effective in restoring most of these values to levels approximating the control group, indicating a potential protective effect of regular exercise against the detrimental impacts of high sucrose dietary consumption on the hypothalamus. Graphical abstract.
摘要：
越来越多的证据表明，蔗糖摄入量的增加可能会导致神经系统疾病的发展。认识到定期锻炼有可能减少神经肌肉疾病的发生，本研究调查了运动对下丘脑氧化还原状态的影响，以减轻与高蔗糖摄入相关的不利影响。40只Wistar白化病大鼠接受了高蔗糖饮食，一些团体进行为期3个月的锻炼。发现运动方案可以维持下丘脑的氧化还原平衡。总之,高蔗糖饮食的消耗导致下丘脑的组织学形态紊乱，伴随着caspase-3阳性细胞百分比的增加。此外,高蔗糖饮食破坏了氧化剂/抗氧化剂的比例，有利于氧化剂，导致AOPP和AGEP水平升高。相反，锻炼有效地将这些值中的大多数恢复到接近对照组的水平，表明定期运动对高蔗糖饮食消耗对下丘脑的有害影响具有潜在的保护作用。图形抽象。
