Abstract：
BACKGROUND: Aging is the primary risk factor of most chronic diseases in humans, including cardiovascular diseases, osteoporosis and neurodegenerative diseases, which extensively damage the quality of life for elderly individuals. Aging is a multifaceted process with numerous factors affecting it. Efficient model organisms are essential for the research and development of anti-aging agents, particularly when investigating pharmacological mechanisms are needed.
OBJECTIVE: This review discusses the application of Caenorhabditis elegans for studying aging and its related signaling pathways, and presents an overview of studies exploring the mechanism and screening of anti-aging agents in C. elegans. Additionally, the review summarizes related clinical trials of anti-aging agents to inspire the development of new medications.
METHODS: Literature was searched, analyzed, and collected using PubMed, Web of Science, and Science Direct. The search terms used were \"anti-aging\", \"medicinal plants\", \"synthetic compounds\", \"C. elegans\", \"signal pathway\", etc. Several combinations of these keywords were used. Studies conducted in C. elegans or humans were included. Articles were excluded, if they were on studies conducted in silico or in vitro or could not offer effective data.
RESULTS: Four compounds mainly derived through synthesis (metformin, rapamycin, nicotinamide mononucleotide, alpha-ketoglutarate) and four active ingredients chiefly obtained from plants (resveratrol, quercetin, Astragalus polysaccharide, ginsenosides) are introduced emphatically. These compounds and active ingredients exhibit potential anti-aging effects in preclinical and clinical studies. The screening of these anti-aging agents and the investigation of their pharmacological mechanisms can benefit from the use of C. elegans.
CONCLUSIONS: Medicinal plants provide valuable resource for the treatment of diseases. A wide source of raw materials for the particular plant medicinal compounds having anti-aging effects meet diverse pharmaceutical requirements, such as immunomodulatory, anti-inflammation and alleviating oxidative stress. C. elegans possesses advantages in scientific research including short life cycle, small size, easy maintenance, genetic tractability and conserved biological processes related to aging. C. elegans can be used for the efficient and rapid evaluation of compounds with the potential to slow down aging.
OBJECTIVE: This review discusses the application of Caenorhabditis elegans for studying aging and its related signaling pathways, and presents an overview of studies exploring the mechanism and screening of anti-aging agents in C. elegans. Additionally, the review summarizes related clinical trials of anti-aging agents to inspire the development of new medications.
METHODS: Literature was searched, analyzed, and collected using PubMed, Web of Science, and Science Direct. The search terms used were \"anti-aging\", \"medicinal plants\", \"synthetic compounds\", \"C. elegans\", \"signal pathway\", etc. Several combinations of these keywords were used. Studies conducted in C. elegans or humans were included. Articles were excluded, if they were on studies conducted in silico or in vitro or could not offer effective data.
RESULTS: Four compounds mainly derived through synthesis (metformin, rapamycin, nicotinamide mononucleotide, alpha-ketoglutarate) and four active ingredients chiefly obtained from plants (resveratrol, quercetin, Astragalus polysaccharide, ginsenosides) are introduced emphatically. These compounds and active ingredients exhibit potential anti-aging effects in preclinical and clinical studies. The screening of these anti-aging agents and the investigation of their pharmacological mechanisms can benefit from the use of C. elegans.
CONCLUSIONS: Medicinal plants provide valuable resource for the treatment of diseases. A wide source of raw materials for the particular plant medicinal compounds having anti-aging effects meet diverse pharmaceutical requirements, such as immunomodulatory, anti-inflammation and alleviating oxidative stress. C. elegans possesses advantages in scientific research including short life cycle, small size, easy maintenance, genetic tractability and conserved biological processes related to aging. C. elegans can be used for the efficient and rapid evaluation of compounds with the potential to slow down aging.
摘要：
背景：衰老是人类大多数慢性疾病的主要危险因素，包括心血管疾病,骨质疏松症和神经退行性疾病，这严重损害了老年人的生活质量。衰老是一个多方面的过程，影响因素众多。高效的模式生物对于抗衰老剂的研究和开发至关重要，特别是当需要研究药理学机制时。
目的：本文综述了秀丽隐杆线虫在研究衰老及其相关信号通路中的应用。并对秀丽隐杆线虫抗衰老剂的机制及筛选研究进行了综述。此外,该综述总结了抗衰老药的相关临床试验，以激发新药的开发。
方法：检索文献，分析,并使用PubMed收集，WebofScience,科学直接。使用的搜索词是“抗衰老”，“药用植物”，“合成化合物”，\"C秀丽隐士\“，\"信号通路\",等。使用了这些关键词的几种组合。包括在秀丽隐杆线虫或人类中进行的研究。文章被排除在外,如果他们是在计算机或体外进行的研究，或者不能提供有效的数据。
结果：主要通过合成获得的四种化合物（二甲双胍，雷帕霉素,烟酰胺单核苷酸,α-酮戊二酸)和四种主要从植物中获得的活性成分(白藜芦醇，槲皮素,黄芪多糖，人参皂苷)重点介绍。这些化合物和活性成分在临床前和临床研究中表现出潜在的抗衰老作用。这些抗衰老剂的筛选及其药理学机制的研究可以受益于秀丽隐杆线虫的使用。
结论：药用植物为疾病的治疗提供了宝贵的资源。具有抗衰老作用的特定植物药化合物的原料来源广泛，可满足多种药物要求。如免疫调节，抗炎和减轻氧化应激。C.线虫在科学研究中具有优势，包括短生命周期，小尺寸,易于维护,遗传可处理性和与衰老相关的保守生物过程。秀丽隐杆线虫可用于高效、疾速评价具有减缓衰老潜能的化合物。
目的：本文综述了秀丽隐杆线虫在研究衰老及其相关信号通路中的应用。并对秀丽隐杆线虫抗衰老剂的机制及筛选研究进行了综述。此外,该综述总结了抗衰老药的相关临床试验，以激发新药的开发。
方法：检索文献，分析,并使用PubMed收集，WebofScience,科学直接。使用的搜索词是“抗衰老”，“药用植物”，“合成化合物”，\"C秀丽隐士\“，\"信号通路\",等。使用了这些关键词的几种组合。包括在秀丽隐杆线虫或人类中进行的研究。文章被排除在外,如果他们是在计算机或体外进行的研究，或者不能提供有效的数据。
结果：主要通过合成获得的四种化合物（二甲双胍，雷帕霉素,烟酰胺单核苷酸,α-酮戊二酸)和四种主要从植物中获得的活性成分(白藜芦醇，槲皮素,黄芪多糖，人参皂苷)重点介绍。这些化合物和活性成分在临床前和临床研究中表现出潜在的抗衰老作用。这些抗衰老剂的筛选及其药理学机制的研究可以受益于秀丽隐杆线虫的使用。
结论：药用植物为疾病的治疗提供了宝贵的资源。具有抗衰老作用的特定植物药化合物的原料来源广泛，可满足多种药物要求。如免疫调节，抗炎和减轻氧化应激。C.线虫在科学研究中具有优势，包括短生命周期，小尺寸,易于维护,遗传可处理性和与衰老相关的保守生物过程。秀丽隐杆线虫可用于高效、疾速评价具有减缓衰老潜能的化合物。
