PDF(Pubmed)
Abstract：
Men who have sex with men and people living with HIV are disproportionately affected in the 2022 multi-country monkeypox epidemic. The smallpox vaccine can induce cross-reactive antibodies against the monkeypox virus (MPXV) and reduce the risk of infection. Data on antibodies against MPXV induced by historic smallpox vaccination in people with HIV are scarce. In this observational study, plasma samples were collected from people living with and without HIV in Shenzhen, China. We measured antibodies binding to two representative proteins of vaccinia virus (VACV; A27L and A33R) and homologous proteins of MPXV (A29L and A35R) using an enzyme-linked immunosorbent assay. We compared the levels of these antibodies between people living with and without HIV. Stratified analyses were performed based on the year of birth of 1981 when the smallpox vaccination was stopped in China. Plasma samples from 677 people living with HIV and 746 people without HIV were tested. A consistent pattern was identified among the four antibodies, regardless of HIV status. VACV antigen-reactive and MPXV antigen-reactive antibodies induced by historic smallpox vaccination were detectable in the people born before 1981, and antibody levels reached a nadir during or after 1981. The levels of smallpox vaccine-induced antibodies were comparable between people living with HIV and those without HIV. Our findings suggest that the antibody levels against MPXV decreased in both people living with and without HIV due to the cessation of smallpox vaccination.
摘要：
在2022年多国猴痘流行中，男男性行为者和艾滋病毒携带者受到的影响不成比例。天花疫苗可以诱导抗猴痘病毒（MPXV）的交叉反应抗体，并降低感染风险。关于HIV感染者中由历史天花疫苗接种诱导的MPXV抗体的数据很少。在这项观察性研究中,从深圳的艾滋病毒携带者和非艾滋病毒携带者身上采集血浆样本，中国。我们使用酶联免疫吸附测定法测量了与痘苗病毒的两种代表性蛋白（VACV;A27L和A33R）和MPXV的同源蛋白（A29L和A35R）结合的抗体。我们比较了有和没有艾滋病毒的人之间这些抗体的水平。根据1981年中国停止天花疫苗接种的出生年份进行了分层分析。对677名HIV感染者和746名HIV感染者的血浆样本进行了测试。在四种抗体中鉴定出一致的模式，无论艾滋病毒状况如何。在1981年之前出生的人中可检测到由历史性天花疫苗接种诱导的VACV抗原反应性和MPXV抗原反应性抗体，并且抗体水平在1981年或之后达到最低点。天花疫苗诱导的抗体水平在艾滋病毒感染者和没有艾滋病毒的人之间是相当的。我们的发现表明，由于停止了天花疫苗接种，有和没有艾滋病毒的人针对MPXV的抗体水平都有所下降。
