Abstract：
OBJECTIVE: Parkinson\'s disease (PD) is characterized by loss of dopamine neurons in the brain, which leads to motor dysfunction; excessive inflammation induces neuronal death. This study aimed to determine the most effective exercise modality to improve motor dysfunction in PD by comparing three different exercise regimens (low-intensity treadmill, high-intensity treadmill, and swimming).
METHODS: The rat model for PD was established through stereotaxic surgery, inducing unilateral 6-OHDA (6-hydroxydopamine) lesions. The low-intensity treadmill regimen exerted better protective effects on neurological and motor functions in a rat model of unilateral 6-OHDA-induced PD compared to high-intensity treadmill and swimming. The most suitable exercise regimen and the optimal duration of daily exercise (15 or 30 min) on motor activity and oxidative stress parameters were evaluated.
RESULTS: Comparison of 15 and 30 min low-intensity treadmill regimens (10 m/min) revealed 30 min daily exercise was the optimal duration and had more favorable impacts on neurological and motor function. Furthermore, we assessed the neuroprotective effects of exercising for 15 and 30 min per day for either four or ten weeks; 30 min of daily exercise for ten weeks improved mitochondrial function, the antioxidant defense system, neurotrophic factors, and muscle mass, and thereby provided protection against dopaminergic neuron loss, and motor dysfunction in rats with 6-OHDA-induced PD.
CONCLUSIONS: 30 min of daily low-intensity treadmill exercise over 10 weeks resulted in heightened mitochondrial function in both muscle and brain tissues, therefore, yielded a neuroprotective effect against the loss of dopaminergic neurons and motor dysfunction in PD rats.
METHODS: The rat model for PD was established through stereotaxic surgery, inducing unilateral 6-OHDA (6-hydroxydopamine) lesions. The low-intensity treadmill regimen exerted better protective effects on neurological and motor functions in a rat model of unilateral 6-OHDA-induced PD compared to high-intensity treadmill and swimming. The most suitable exercise regimen and the optimal duration of daily exercise (15 or 30 min) on motor activity and oxidative stress parameters were evaluated.
RESULTS: Comparison of 15 and 30 min low-intensity treadmill regimens (10 m/min) revealed 30 min daily exercise was the optimal duration and had more favorable impacts on neurological and motor function. Furthermore, we assessed the neuroprotective effects of exercising for 15 and 30 min per day for either four or ten weeks; 30 min of daily exercise for ten weeks improved mitochondrial function, the antioxidant defense system, neurotrophic factors, and muscle mass, and thereby provided protection against dopaminergic neuron loss, and motor dysfunction in rats with 6-OHDA-induced PD.
CONCLUSIONS: 30 min of daily low-intensity treadmill exercise over 10 weeks resulted in heightened mitochondrial function in both muscle and brain tissues, therefore, yielded a neuroprotective effect against the loss of dopaminergic neurons and motor dysfunction in PD rats.
摘要：
目的：帕金森病（PD）的特征是大脑中多巴胺神经元的丢失，导致运动障碍；过度炎症诱导神经元死亡。本研究旨在通过比较三种不同的运动方案（低强度跑步机，高强度跑步机,游泳）。
方法：通过立体定向手术建立PD大鼠模型，诱导单侧6-OHDA（6-羟基多巴胺）病变。与高强度跑步机和游泳相比，低强度跑步机方案对单侧6-OHDA诱导的PD大鼠模型的神经和运动功能具有更好的保护作用。评估了运动活动和氧化应激参数的最合适的运动方案和每日运动的最佳持续时间（15或30分钟）。
结果：比较15分钟和30分钟的低强度跑步机方案（10m/min）显示，每天30分钟的运动是最佳持续时间，对神经和运动功能有更有利的影响。此外，我们评估了每天运动15分钟和30分钟，持续4周或10周的神经保护作用；每天运动30分钟，持续10周改善线粒体功能，抗氧化防御系统,神经营养因子，和肌肉质量，从而提供了防止多巴胺能神经元丢失的保护，6-OHDA诱导的PD大鼠的运动功能障碍。
结论：在10周内每天30分钟的低强度跑步机运动导致肌肉和脑组织线粒体功能增强，因此,对PD大鼠多巴胺能神经元的丢失和运动障碍产生神经保护作用。
方法：通过立体定向手术建立PD大鼠模型，诱导单侧6-OHDA（6-羟基多巴胺）病变。与高强度跑步机和游泳相比，低强度跑步机方案对单侧6-OHDA诱导的PD大鼠模型的神经和运动功能具有更好的保护作用。评估了运动活动和氧化应激参数的最合适的运动方案和每日运动的最佳持续时间（15或30分钟）。
结果：比较15分钟和30分钟的低强度跑步机方案（10m/min）显示，每天30分钟的运动是最佳持续时间，对神经和运动功能有更有利的影响。此外，我们评估了每天运动15分钟和30分钟，持续4周或10周的神经保护作用；每天运动30分钟，持续10周改善线粒体功能，抗氧化防御系统,神经营养因子，和肌肉质量，从而提供了防止多巴胺能神经元丢失的保护，6-OHDA诱导的PD大鼠的运动功能障碍。
结论：在10周内每天30分钟的低强度跑步机运动导致肌肉和脑组织线粒体功能增强，因此,对PD大鼠多巴胺能神经元的丢失和运动障碍产生神经保护作用。
