脊髓小脑共济失调3型(SCA3)是一种常染色体显性神经退行性疾病,可引起运动不协调和进行性功能障碍。尽管药物干预已显示出SCA3管理的前景,但不良反应可能变得难以承受。在中药(TCM)中使用草药可以作为延缓疾病进展的潜在替代药物。本系统审查旨在确定,评价,并总结了有关中药靶向氧化应激在SCA3管理中的治疗作用的研究结果。在三个数据库中检索2013年1月1日至2023年6月30日发表的相关文章,即PubMed,WebofScience,还有Scopus,根据系统审查和荟萃分析(PRISMA)的首选报告项目的程序进行。共有10项临床前研究符合系统评价的纳入标准。我们认识到甘蓝型油菜的治疗潜力,党参,姜黄sp.,栀子,天麻,银杏,膨胀甘草,猴头菌,Hyptissp.,芍药,人参,Poriacocos,葛根,地黄,和玄参。我们确定了表达聚谷氨酰胺(polyQ)扩增突变蛋白(mATXN3)的临床前模型的类型,模拟SCA3发病机制的氧化应激诱导剂,和有效剂量的草药。有助于减弱氧化应激的作用方式是激活抗氧化剂途径,泛素-蛋白酶体系统和自噬,细胞凋亡的调节,促炎信号通路和伴侣,调节线粒体功能和生物发生,神经传递和突触可塑性的恢复。总之,中药中草药可能延缓SCA3的进展,因此为临床试验提供了依据.
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder that gives rise to motor incoordination and progressive functional disabilities. Although pharmacological interventions have revealed promising prospects in the management of SCA3, adverse effects may become unbearable. The use of herbal remedies in traditional Chinese medicine (TCM) may serve as potential alternative medicines to delay the progression of the disease. This systematic review is intended to identify, appraise, and summarize the findings of studies pertaining to the therapeutic roles of herbal remedies in TCM targeting oxidative stress in the management of SCA3. A literature search for relevant articles published from 1 January 2013 to 30 June 2023 in three databases, namely PubMed, Web of Science, and Scopus, was carried out according to the procedures of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A total of ten preclinical studies met the inclusion criteria of the systematic review. We recognized the therapeutic potential of Brassica napus, Codonopsis pilosula, Curcuma sp., Gardenia jasminoides, Gastrodia elata, Ginkgo biloba, Glycyrrhiza inflata, Hericium erinaceus, Hyptis sp., Paeonia lactiflora, Panax ginseng, Poria cocos, Pueraria lobata, Rehmannia glutinosa, and Scrophularia ningpoensis. We identified the types of preclinical models expressing polyglutamine (polyQ) expanded mutant protein (mATXN3), inducers of oxidative stress that mimic the SCA3 pathogenesis, and effective doses of the herbal remedies. The modes of action contributing to the attenuation of oxidative stress are activation of antioxidant pathways, ubiquitin-proteasome system and autophagy, regulation of apoptosis, proinflammatory signaling pathway and chaperones, regulation of mitochondrial function and biogenesis, and restoration of neurotransmission and synaptic plasticity. In conclusion, herbal remedies in TCM may possibly delay the progression of SCA3, therefore providing justification for clinical trials.