Abstract：
BACKGROUND: Differentiation therapy, a highly regarded treatment method in tumor research, aims to induce tumor cells to differentiate back to normal cells, deviating from the malignant pathway and returning to a benign state. Its development relies on the continuous discovery of efficient and low-toxic differentiation inducers, including plant-derived active components that offer significant biological utilization and therapeutic potential. For this reason, the exploration of plant-derived inducers, particularly in their application in differentiation therapy, holds great promise in advancing cancer treatment strategies toward more effective and safer alternatives.
OBJECTIVE: This paper aims to provide a valuable reference for researchers seeking to identify natural, efficient, and low-toxic differentiation inducers from plants and highlights a promising research direction for the application of differentiation therapy in malignant tumor treatment.
METHODS: For the collection of pertinent information, an extensive search was conducted across diverse literature and electronic databases, including PubMed, ScienceDirect, Wiley, ACS, CNKI, Springer, Taylor & Francis, Web of Science, Google Scholar, and Baidu Scholar. This comprehensive approach aimed to retrieve and include all relevant literature from 1985 to 2023. Primary keywords such as \"Natural medicinal plant,\" \"Differentiation therapy,\" and \"Differentiation inducer\" were utilized, supplemented by secondary search terms including \"Cancer,\" \"Tumor,\" \"Herbal medicine,\" \"Induced differentiation,\" and \"Cancer treatment.\"
RESULTS: This study systematically evaluated the application of plant-derived inducers in tumor-induced differentiation therapy. Through extensive literature review, specific plant components with confirmed differentiation-inducing properties were identified. Furthermore, potential molecular mechanisms underlying this process were outlined, shedding light on the future development of differentiation therapy in cancer treatment.
CONCLUSIONS: Plant-derived active components exhibit substantial biological utility and therapeutic potential. Delving deeper into the research on these components as differentiation inducers holds promise for the selection of novel cancer drugs and the unveiling of novel pathways for cancer treatment. These results emphasize the importance of continued exploration and in-depth research into natural, efficient, and low-toxic differentiation inducers from plants, which could significantly advance cancer treatment strategies. Moreover, the highlighted research direction underscores the relevance of differentiation therapy in the context of malignant tumor treatment, indicating its potential as a safer and more effective alternative in cancer therapy.
OBJECTIVE: This paper aims to provide a valuable reference for researchers seeking to identify natural, efficient, and low-toxic differentiation inducers from plants and highlights a promising research direction for the application of differentiation therapy in malignant tumor treatment.
METHODS: For the collection of pertinent information, an extensive search was conducted across diverse literature and electronic databases, including PubMed, ScienceDirect, Wiley, ACS, CNKI, Springer, Taylor & Francis, Web of Science, Google Scholar, and Baidu Scholar. This comprehensive approach aimed to retrieve and include all relevant literature from 1985 to 2023. Primary keywords such as \"Natural medicinal plant,\" \"Differentiation therapy,\" and \"Differentiation inducer\" were utilized, supplemented by secondary search terms including \"Cancer,\" \"Tumor,\" \"Herbal medicine,\" \"Induced differentiation,\" and \"Cancer treatment.\"
RESULTS: This study systematically evaluated the application of plant-derived inducers in tumor-induced differentiation therapy. Through extensive literature review, specific plant components with confirmed differentiation-inducing properties were identified. Furthermore, potential molecular mechanisms underlying this process were outlined, shedding light on the future development of differentiation therapy in cancer treatment.
CONCLUSIONS: Plant-derived active components exhibit substantial biological utility and therapeutic potential. Delving deeper into the research on these components as differentiation inducers holds promise for the selection of novel cancer drugs and the unveiling of novel pathways for cancer treatment. These results emphasize the importance of continued exploration and in-depth research into natural, efficient, and low-toxic differentiation inducers from plants, which could significantly advance cancer treatment strategies. Moreover, the highlighted research direction underscores the relevance of differentiation therapy in the context of malignant tumor treatment, indicating its potential as a safer and more effective alternative in cancer therapy.
摘要：
背景：分化治疗，肿瘤研究中备受推崇的治疗方法，目的是诱导肿瘤细胞分化回正常细胞，偏离恶性途径，回到良性状态。它的发展依赖于不断发现高效低毒的分化诱导剂,包括植物衍生的活性成分，提供显著的生物利用和治疗潜力。出于这个原因,植物衍生诱导剂的探索，特别是在分化治疗中的应用，在推动癌症治疗策略朝着更有效和更安全的替代方案发展方面具有巨大的前景。
目的：本文旨在为寻求鉴别自然、高效,和低毒的植物分化诱导剂，为分化疗法在恶性肿瘤治疗中的应用指明了有希望的研究方向。
方法：为了收集相关信息，在各种文献和电子数据库中进行了广泛的搜索，包括PubMed,ScienceDirect,威利,ACS,CNKI,Springer,泰勒和弗朗西斯，WebofScience,谷歌学者，和百度学者。这种全面的方法旨在检索并包括1985年至2023年的所有相关文献。主要关键词如“天然药用植物,\"\"分化治疗,“和”分化诱导剂“被利用，辅以次要搜索术语，包括“癌症，\"\"肿瘤,\"\"草药,“\”诱导分化，“和”癌症治疗。\"
结果：本研究系统评估了植物来源的诱导剂在肿瘤诱导分化治疗中的应用。通过广泛的文献综述，鉴定了具有证实的分化诱导特性的特定植物成分。此外，概述了这一过程的潜在分子机制，展望分化治疗在肿瘤治疗中的未来发展。
结论：植物来源的活性成分表现出巨大的生物效用和治疗潜力。深入研究这些成分作为分化诱导剂的研究有望选择新型癌症药物并揭示癌症治疗的新途径。这些结果强调了继续探索和深入研究自然的重要性，高效,和低毒的植物分化诱导剂，这可以显著推进癌症治疗策略。此外，突出的研究方向强调了分化治疗在恶性肿瘤治疗中的相关性，表明其作为癌症治疗中更安全、更有效的替代方案的潜力。
目的：本文旨在为寻求鉴别自然、高效,和低毒的植物分化诱导剂，为分化疗法在恶性肿瘤治疗中的应用指明了有希望的研究方向。
方法：为了收集相关信息，在各种文献和电子数据库中进行了广泛的搜索，包括PubMed,ScienceDirect,威利,ACS,CNKI,Springer,泰勒和弗朗西斯，WebofScience,谷歌学者，和百度学者。这种全面的方法旨在检索并包括1985年至2023年的所有相关文献。主要关键词如“天然药用植物,\"\"分化治疗,“和”分化诱导剂“被利用，辅以次要搜索术语，包括“癌症，\"\"肿瘤,\"\"草药,“\”诱导分化，“和”癌症治疗。\"
结果：本研究系统评估了植物来源的诱导剂在肿瘤诱导分化治疗中的应用。通过广泛的文献综述，鉴定了具有证实的分化诱导特性的特定植物成分。此外，概述了这一过程的潜在分子机制，展望分化治疗在肿瘤治疗中的未来发展。
结论：植物来源的活性成分表现出巨大的生物效用和治疗潜力。深入研究这些成分作为分化诱导剂的研究有望选择新型癌症药物并揭示癌症治疗的新途径。这些结果强调了继续探索和深入研究自然的重要性，高效,和低毒的植物分化诱导剂，这可以显著推进癌症治疗策略。此外，突出的研究方向强调了分化治疗在恶性肿瘤治疗中的相关性，表明其作为癌症治疗中更安全、更有效的替代方案的潜力。
