柴胡皂苷D,一种皂苷化合物,是从柴胡中提取的,是该植物的主要活性成分。它具有多种药理作用,包括抗炎,抗氧化剂,免疫调节,新陈代谢,和抗肿瘤特性,近年来在抗肿瘤研究中引起了极大的关注。研究表明柴胡皂苷D抑制多种肿瘤细胞的增殖,抑制肝癌等癌症的进展,胰腺,肺,神经胶质瘤,卵巢,甲状腺,胃,和乳腺癌。其抗肿瘤机制主要涉及抑制肿瘤细胞增殖,促进肿瘤细胞凋亡,阻止肿瘤细胞侵袭,和调节肿瘤细胞自噬。此外,柴胡皂苷D可增强对抗肿瘤药物的敏感性并增强机体免疫力。鉴于其多方面的抗肿瘤作用,柴胡皂苷D在抗肿瘤治疗中具有广阔的潜力。本文综述了近年来关于其抗肿瘤作用的研究,旨在为临床癌症治疗提供新的理论见解。
Saikosaponin D, a saponin compound, is extracted from Bupleurum and is a principal active component of the plant. It boasts a variety of pharmacologic effects including anti-inflammatory, antioxidant, immunomodulatory, metabolic, and anti-tumor properties, drawing significant attention in anti-
tumor research in recent years. Research indicates that saikosaponin D inhibits the proliferation of numerous tumor cells, curbing the progression of cancers such as liver, pancreatic, lung, glioma, ovarian, thyroid, stomach, and breast cancer. Its anti-
tumor mechanisms largely involve inhibiting
tumor cell proliferation, promoting
tumor cell apoptosis, thwarting
tumor-cell invasion, and modulating
tumor cell autophagy. Moreover, saikosaponin D enhances the sensitivity to anti-
tumor drugs and augments body immunity. Given its multi-faceted anti-
tumor roles, saikosaponin D offers promising potential in anti-
tumor therapy. This paper reviews recent studies on its anti-tumor effects, aiming to furnish new theoretical insights for clinical cancer treatments.