METHODS: This study included older adults aged ≥ 65 years without dementia from the Health and Retirement Study. We combined participants with MCR information in 2006 and 2008 as baseline, and the participants were followed up 4 and 8 years later. The states of pain interference were divided into 3 categories: interfering pain, non-interfering pain, and no pain. Logistic regression analysis was done at baseline to examine the associations between pain interference and concurrent MCR. During the 8-year follow-up, Cox regression analysis was done to investigate the associations between pain interference and incident MCR.
RESULTS: The study included 7120 older adults (74.6 ± 6.7 years; 56.8% females) at baseline. The baseline prevalence of MCR was 5.7%. Individuals with interfering pain had a significantly increased risk of MCR (OR = 1.51, 95% CI = 1.17-1.95; p = 0.001). The longitudinal analysis included 4605 participants, and there were 284 (6.2%) MCR cases on follow-up. Participants with interfering pain at baseline had a higher risk for MCR at 8 years of follow-up (HR = 2.02, 95% CI = 1.52-2.69; p < 0.001).
CONCLUSIONS: Older adults with interfering pain had a higher risk for MCR versus those with non-interfering pain or without pain. Timely and adequate management of interfering pain may contribute to the prevention and treatment of MCR and its associated adverse outcomes.
方法:本研究纳入健康与退休研究中年龄≥65岁无痴呆的老年人。我们将参与者与2006年和2008年的MCR信息相结合作为基线,参与者在4年和8年后接受了随访.疼痛干扰的状态分为3类:干扰疼痛,非干扰性疼痛,也没有疼痛.在基线时进行Logistic回归分析,以检查疼痛干扰与并发MCR之间的关联。在为期8年的随访中,进行Cox回归分析以研究疼痛干扰与事件MCR之间的关联。
结果:该研究纳入了基线时7120名老年人(74.6±6.7岁;56.8%为女性)。MCR的基线患病率为5.7%。干预疼痛的个体MCR风险显著增加(OR=1.51,95%CI=1.17-1.95;p=0.001)。纵向分析包括4605名参与者,随访中有284例(6.2%)MCR病例。基线时干预疼痛的参与者在随访8年时MCR的风险更高(HR=2.02,95%CI=1.52-2.69;p<0.001)。
结论:患有干预性疼痛的老年人与患有非干预性疼痛或无疼痛的老年人相比,患MCR的风险更高。及时和充分的干预疼痛管理可能有助于MCR及其相关不良结局的预防和治疗。