{Reference Type}: Journal Article
{Title}: Association between pain interference and motoric cognitive risk syndrome in older adults: a population-based cohort study.
{Author}: Li G;He Z;Hu J;Xiao C;Fan W;Zhang Z;Yao Q;Zou J;Huang G;Zeng Q;
{Journal}: BMC Geriatr
{Volume}: 24
{Issue}: 1
{Year}: 2024 May 17
{Factor}: 4.07
{DOI}: 10.1186/s12877-024-04974-7
{Abstract}: <B>OBJECTIVE: </B>Motoric cognitive risk syndrome (MCR) is a pre-dementia condition characterized by subjective complaints in cognition and slow gait. Pain interference has previously been linked with cognitive deterioration; however, its specific relationship with MCR remains unclear. We aimed to examine how pain interference is associated with concurrent and incident MCR.<BR><B>METHODS: </B>This study included older adults aged ≥ 65 years without dementia from the Health and Retirement Study. We combined participants with MCR information in 2006 and 2008 as baseline, and the participants were followed up 4 and 8 years later. The states of pain interference were divided into 3 categories: interfering pain, non-interfering pain, and no pain. Logistic regression analysis was done at baseline to examine the associations between pain interference and concurrent MCR. During the 8-year follow-up, Cox regression analysis was done to investigate the associations between pain interference and incident MCR.<BR><B>RESULTS: </B>The study included 7120 older adults (74.6 ± 6.7 years; 56.8% females) at baseline. The baseline prevalence of MCR was 5.7%. Individuals with interfering pain had a significantly increased risk of MCR (OR = 1.51, 95% CI = 1.17-1.95; p = 0.001). The longitudinal analysis included 4605 participants, and there were 284 (6.2%) MCR cases on follow-up. Participants with interfering pain at baseline had a higher risk for MCR at 8 years of follow-up (HR = 2.02, 95% CI = 1.52-2.69; p < 0.001).<BR><B>CONCLUSIONS: </B>Older adults with interfering pain had a higher risk for MCR versus those with non-interfering pain or without pain. Timely and adequate management of interfering pain may contribute to the prevention and treatment of MCR and its associated adverse outcomes.