Abstract：
Medicinal plants contain a wide variety of bioactive phytoconstituents which can serve as new therapeutic agents for several diseases. This study examines the antidiabetic potential of Aitchisonia rosea in alloxan-induced diabetic rats and identifies its bioactive phytoconstituents using GC-MS. In vitro, antidiabetic potential was established using the α-amylase inhibition assay. In vivo, antidiabetic potential was investigated by employing the oral glucose tolerance test (OGTT). GC-MS analysis was used to identify the bioactive phytoconstituents. The in vitro and in vivo tests showed that the aqueous extract of A. rosea possesses better antidiabetic potential. The α-amylase inhibition assay highlighted an IC50 value of 134.87µg/ml. In an oral glucose tolerance test, rats given an aqueous A. rosea extract significantly lowered their blood sugar levels significant reduction in the blood glucose concentration was observed in the oral glucose tolerance test in rats treated with the aqueous A. rosea extract. GC-MS investigation revealed many phytoconstituents, with serverogenin acetate and cycloheptasiloxane tetradecamethyl being important antidiabetic agents. This study found anti-diabetic properties in A. rosea extract. The phytochemical and GC-MS investigation also found serverogenin acetate and cycloheptasiloxane tetradecamethyl, which could be used to develop new antidiabetic drugs.
摘要：
药用植物含有多种生物活性植物成分，可作为几种疾病的新治疗剂。这项研究检查了四氧嘧啶诱导的糖尿病大鼠的抗糖尿病潜力，并使用GC-MS鉴定了其生物活性植物成分。体外，使用α-淀粉酶抑制试验建立抗糖尿病潜力。在体内,通过口服葡萄糖耐量试验(OGTT)研究抗糖尿病潜力.GC-MS分析用于鉴定生物活性植物成分。体外和体内试验表明，玫瑰草的水提取物具有更好的抗糖尿病潜力。α-淀粉酶抑制测定法突出显示了134.87μg/ml的IC50值。在口服葡萄糖耐量试验中，在口服葡萄糖耐量试验中,在给予玫瑰A.rosea提取物水溶液的大鼠中,观察到血糖浓度显著降低。GC-MS研究揭示了许多植物成分，与serverogenin乙酸盐和环七硅氧烷十四甲基是重要的抗糖尿病药物。这项研究发现了玫瑰曲霉提取物的抗糖尿病特性。植物化学和GC-MS研究还发现了乙酸serverogenin和环庚硅氧烷十四甲基，可用于开发新的抗糖尿病药物。
