Abstract：
In the last decades, the consumption of energy drinks has risen dramatically, especially among young people, adolescents and athletes, driven by the constant search for ergogenic effects, such as the increase in physical and cognitive performance. In parallel, mixed consumption of energy drinks and ethanol, under a binge drinking modality, under a binge drinking modality, has similarly grown among adolescents. However, little is known whether the combined consumption of these drinks, during adolescence, may have long-term effects on central function, raising the question of the risks of this habit on brain maturation. Our study was designed to evaluate, by behavioral, electrophysiological and molecular approaches, the long-term effects on hippocampal plasticity of ethanol (EtOH), energy drinks (EDs), or alcohol mixed with energy drinks (AMED) in a rat model of binge-like drinking adolescent administration. The results show that AMED binge-like administration produces adaptive hippocampal changes at the molecular level, associated with electrophysiological and behavioral alterations, which develop during the adolescence and are still detectable in adult animals. Overall, the study indicates that binge-like drinking AMED adolescent exposure represents a habit that may affect permanently hippocampal plasticity.
摘要：
在过去的几十年里，能量饮料的消费量急剧上升，尤其是年轻人,青少年和运动员，在不断寻找人体效应的驱动下，例如身体和认知表现的提高。并行,混合消费能量饮料和乙醇，在狂饮模式下，在狂饮模式下，在青少年中也同样成长。然而,鲜为人知的是，这些饮料的综合消费，在青春期,可能会对中枢功能产生长期影响，提出了这种习惯对大脑成熟的风险的问题。我们的研究旨在评估，通过行为，电生理学和分子方法，乙醇（EtOH）对海马可塑性的长期影响，能量饮料（ED），或酒精与能量饮料（AMED）混合在青少年暴饮暴食的大鼠模型中。结果表明，AMED暴饮暴食样给药在分子水平上产生适应性海马变化，与电生理和行为改变有关，在青春期发育，在成年动物中仍然可以检测到。总的来说,这项研究表明，暴饮暴食的AMED青少年暴露代表一种习惯，可能会影响海马的永久性可塑性。
