■饮酒与心血管疾病有关,交感神经系统是一个可疑的介体。本研究调查了肌肉交感神经活动对休息时血压的交感神经转导,以及对夜间酗酒或液体控制后的冷加压试验的反应,假设在暴饮暴食后的早晨,交感神经传导会升高。
■使用随机化,流体控制(FC)交叉设计,26名健康成年人(12名男性,14女,25±6年,27±4kg/m2)接受了夜间狂欢酒精剂量和FC。所有参与者都接受了第二天早上的自主神经心血管测试,包括肌肉交感神经活动,血压逐级跳动,和心率在10分钟的休息期间和2分钟的冷加压测试。在两种实验条件下,在静止和冷加压试验期间评估交感神经转导。
■晚上饮酒会增加心率(FC:60±9对酒精:64±9bpm;P=0.010),但不会改变静息平均动脉压(FC:80±6对酒精:80±7mmHg;P=0.857)或肌肉交感神经活动(FC:18±9对酒精:20±8爆发/分钟;P=0.283)。交感神经传导至平均动脉压(时间×条件;P=0.003),舒张压(时间×状况;P=0.010),静息饮酒后,血管总电导(时间×条件;P=0.004)增加。寒冷加压试验期间的交感神经传导在晚上酗酒后也升高(P=0.002)。
这些发现表明,晚上暴饮暴食会导致肌肉交感神经活动对血压的交感神经传导增强,强调了一种新的机制,即慢性或过量饮酒通过改变终末器官对交感神经流出的反应性来促进心血管疾病的进展。
■URL:https://www。clinicaltrials.gov;唯一标识符:NCT03567434。
UNASSIGNED: Alcohol consumption is associated with cardiovascular disease, and the sympathetic nervous system is a suspected mediator. The present study investigated sympathetic transduction of muscle sympathetic nerve activity to blood pressure at rest and in response to cold pressor test following evening binge alcohol or fluid control, with the hypothesis that sympathetic transduction would be elevated the morning after binge alcohol consumption.
UNASSIGNED: Using a randomized, fluid-controlled (FC) crossover design, 26 healthy adults (12 male, 14 female, 25±6 years, 27±4 kg/m2) received an evening binge alcohol dose and a FC. All participants underwent next-morning autonomic-cardiovascular testing consisting of muscle sympathetic nerve activity, beat-to-beat blood pressure, and heart rate during a 10-minute rest period and a 2-minute cold pressor test. Sympathetic transduction was assessed at rest and during the cold pressor test in both experimental conditions.
UNASSIGNED: Evening alcohol increased heart rate (FC: 60±9 versus alcohol: 64±9 bpm; P=0.010) but did not alter resting mean arterial pressure (FC: 80±6 versus alcohol: 80±7 mm Hg; P=0.857) or muscle sympathetic nerve activity (FC: 18±9 versus alcohol: 20±8 bursts/min; P=0.283). Sympathetic transduction to mean arterial pressure (time×condition; P=0.003), diastolic blood pressure (time×condition; P=0.010), and total vascular conductance (time×condition; P=0.004) was augmented after alcohol at rest. Sympathetic transduction during the cold pressor test was also elevated after evening binge alcohol consumption (P=0.002).
UNASSIGNED: These findings suggest that evening binge alcohol consumption leads to augmented morning-after sympathetic transduction of muscle sympathetic nerve activity to blood pressure, highlighting a new mechanism whereby chronic or excessive alcohol consumption contributes to cardiovascular disease progression via altered end-organ responsiveness to sympathetic neural outflow.
UNASSIGNED: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03567434.