Abstract：
UNASSIGNED: This study aims to examine whether the genetic variants in the genes for Granzyme B (GZMB) and Interferon Induced with Helicase C domain 1 (IFIH1) were associated with psoriasis.
UNASSIGNED: Psoriasis, a papulosquamous skin disease, was initially thought of as a disorder primarily of epidermal keratinocytes but is now recognized as one of the most common immune-mediated disorders. It is caused by the interplay between multiple genetic and environmental risk factors.
UNASSIGNED: This case-control study has 65 participants with psoriasis and 65 healthy controls. Real-time PCR was used to genotype GZMB (rs8192917) and IFIH1 (rs35667974).
UNASSIGNED: Genotype occurrence and allelic spreading for both SNPs are in Hardy - Weinberg equilibrium. The genotype and allele distributions of rs35667974 showed no differences between the studied groups. Regarding rs8192917, compared to Group II, there is a statistically significant rise in the CC genotype and C allele in Group I. Higher PASI scores are detected in the C/C and C/T genotypes more than the T/T genotype. Univariate and multivariate analyses revealed that BMI, catalase, MDA, and rs8192917 (C/C) are associated with psoriasis.
UNASSIGNED: GZMB rs8192917 was significantly related to psoriasis risk; its C allele is likewise associated with psoriasis vulnerability. However, our investigation found no link between rs35667974 and psoriasis.
UNASSIGNED: Psoriasis, a papulosquamous skin disease, was initially thought of as a disorder primarily of epidermal keratinocytes but is now recognized as one of the most common immune-mediated disorders. It is caused by the interplay between multiple genetic and environmental risk factors.
UNASSIGNED: This case-control study has 65 participants with psoriasis and 65 healthy controls. Real-time PCR was used to genotype GZMB (rs8192917) and IFIH1 (rs35667974).
UNASSIGNED: Genotype occurrence and allelic spreading for both SNPs are in Hardy - Weinberg equilibrium. The genotype and allele distributions of rs35667974 showed no differences between the studied groups. Regarding rs8192917, compared to Group II, there is a statistically significant rise in the CC genotype and C allele in Group I. Higher PASI scores are detected in the C/C and C/T genotypes more than the T/T genotype. Univariate and multivariate analyses revealed that BMI, catalase, MDA, and rs8192917 (C/C) are associated with psoriasis.
UNASSIGNED: GZMB rs8192917 was significantly related to psoriasis risk; its C allele is likewise associated with psoriasis vulnerability. However, our investigation found no link between rs35667974 and psoriasis.
摘要：
■本研究旨在检查解旋酶C结构域1(IFIH1)诱导的粒酶B(GZMB)和干扰素基因中的遗传变异是否与银屑病相关。
■牛皮癣，丘疹鳞状皮肤病,最初被认为是主要由表皮角质形成细胞引起的疾病，但现在被认为是最常见的免疫介导疾病之一。它是由多种遗传和环境风险因素之间的相互作用引起的。
■这项病例对照研究有65名银屑病患者和65名健康对照者。使用实时PCR对GZMB(rs8192917)和IFIH1(rs35667974)进行基因分型。
■两个SNP的基因型发生和等位基因传播处于Hardy-Weinberg平衡。rs35667974的基因型和等位基因分布在研究组之间没有差异。关于rs8192917，与第二组相比，I组中CC基因型和C等位基因有统计学意义的升高。在C/C和C/T基因型中检测到的PASI得分高于T/T基因型。单因素和多因素分析显示，BMI，过氧化氢酶,MDA,rs8192917(C/C)与银屑病相关。
■GZMBrs8192917与银屑病风险显著相关；其C等位基因同样与银屑病易损性相关。然而,我们的调查发现rs35667974和银屑病之间没有联系.
■牛皮癣，丘疹鳞状皮肤病,最初被认为是主要由表皮角质形成细胞引起的疾病，但现在被认为是最常见的免疫介导疾病之一。它是由多种遗传和环境风险因素之间的相互作用引起的。
■这项病例对照研究有65名银屑病患者和65名健康对照者。使用实时PCR对GZMB(rs8192917)和IFIH1(rs35667974)进行基因分型。
■两个SNP的基因型发生和等位基因传播处于Hardy-Weinberg平衡。rs35667974的基因型和等位基因分布在研究组之间没有差异。关于rs8192917，与第二组相比，I组中CC基因型和C等位基因有统计学意义的升高。在C/C和C/T基因型中检测到的PASI得分高于T/T基因型。单因素和多因素分析显示，BMI，过氧化氢酶,MDA,rs8192917(C/C)与银屑病相关。
■GZMBrs8192917与银屑病风险显著相关；其C等位基因同样与银屑病易损性相关。然而,我们的调查发现rs35667974和银屑病之间没有联系.
