%0 Journal Article
%T Identifying the association between polymorphisms in the GZMB and IFIH1 genes and psoriasis in Egyptians.
%A Rizk SK
%A Farag AGA
%A El-Ghlban S
%A Eldin Metwally IS
%J J Immunoassay Immunochem
%V 45
%N 3
%D 2024 May 3
%M 38733267
暂无%R 10.1080/15321819.2024.2352496
%X <B>UNASSIGNED: </B>This study aims to examine whether the genetic variants in the genes for Granzyme B (GZMB) and Interferon Induced with Helicase C domain 1 (IFIH1) were associated with psoriasis.<BR><B>UNASSIGNED: </B>Psoriasis, a papulosquamous skin disease, was initially thought of as a disorder primarily of epidermal keratinocytes but is now recognized as one of the most common immune-mediated disorders. It is caused by the interplay between multiple genetic and environmental risk factors.<BR><B>UNASSIGNED: </B>This case-control study has 65 participants with psoriasis and 65 healthy controls. Real-time PCR was used to genotype GZMB (rs8192917) and IFIH1 (rs35667974).<BR><B>UNASSIGNED: </B>Genotype occurrence and allelic spreading for both SNPs are in Hardy - Weinberg equilibrium. The genotype and allele distributions of rs35667974 showed no differences between the studied groups. Regarding rs8192917, compared to Group II, there is a statistically significant rise in the CC genotype and C allele in Group I. Higher PASI scores are detected in the C/C and C/T genotypes more than the T/T genotype. Univariate and multivariate analyses revealed that BMI, catalase, MDA, and rs8192917 (C/C) are associated with psoriasis.<BR><B>UNASSIGNED: </B>GZMB rs8192917 was significantly related to psoriasis risk; its C allele is likewise associated with psoriasis vulnerability. However, our investigation found no link between rs35667974 and psoriasis.