Abstract：
OBJECTIVE: Adolescent and young adults (AYAs) with metastatic breast cancer (MBC) experience high physical and psychosocial burdens compounded by a disrupted life trajectory. We sought to determine the psychosocial and supportive care concerns of this population to better understand and address unmet needs.
METHODS: AYAs diagnosed with MBC (18-39 years) participating in a prospective interventional study (Young, Empowered, and Strong) at Dana-Farber Cancer Institute completed an electronic survey following enrollment. Measures evaluated sociodemographics, health behaviors, quality of life, and symptoms, among others. We used two-sided Fisher\'s exact tests to determine associations between concerns (e.g., cancer progression, side effects, lifestyle, finances, fertility) and demographic variables.
RESULTS: Among 77 participants enrolled from 9/2020-12/2022, average age at MBC diagnosis and survey was 35.9 (range: 22-39) and 38.3 years (range: 27-46), respectively. Most were non-Hispanic white (83.8%) and 40.3% reported their diagnosis caused some financial problems. Many were concerned about fertility (27.0%), long-term treatment side effects (67.6%), exercise (61.6%), and diet (54.1%). Select concerns varied significantly by age, race/ethnicity, and education. Younger women at survey reported greater concern about familial cancer risk (p = 0.028). Women from minority racial/ethnic groups more frequently reported issues talking about their cancer to family/friends (p = 0.040) while those with more education were more frequently concerned with long-term effects of cancer on their health (p = 0.021).
CONCLUSIONS: Young women living with MBC frequently report psychosocial, health, and cancer management concerns. Tailoring supportive care and communications to address prevalent concerns including disease progression and treatment side effects may optimize wellbeing.
METHODS: AYAs diagnosed with MBC (18-39 years) participating in a prospective interventional study (Young, Empowered, and Strong) at Dana-Farber Cancer Institute completed an electronic survey following enrollment. Measures evaluated sociodemographics, health behaviors, quality of life, and symptoms, among others. We used two-sided Fisher\'s exact tests to determine associations between concerns (e.g., cancer progression, side effects, lifestyle, finances, fertility) and demographic variables.
RESULTS: Among 77 participants enrolled from 9/2020-12/2022, average age at MBC diagnosis and survey was 35.9 (range: 22-39) and 38.3 years (range: 27-46), respectively. Most were non-Hispanic white (83.8%) and 40.3% reported their diagnosis caused some financial problems. Many were concerned about fertility (27.0%), long-term treatment side effects (67.6%), exercise (61.6%), and diet (54.1%). Select concerns varied significantly by age, race/ethnicity, and education. Younger women at survey reported greater concern about familial cancer risk (p = 0.028). Women from minority racial/ethnic groups more frequently reported issues talking about their cancer to family/friends (p = 0.040) while those with more education were more frequently concerned with long-term effects of cancer on their health (p = 0.021).
CONCLUSIONS: Young women living with MBC frequently report psychosocial, health, and cancer management concerns. Tailoring supportive care and communications to address prevalent concerns including disease progression and treatment side effects may optimize wellbeing.
摘要：
目标：患有转移性乳腺癌（MBC）的青少年和年轻人（AYAs）经历了很高的身体和心理社会负担，生活轨迹被破坏。我们试图确定该人群的社会心理和支持性护理问题，以更好地理解和解决未满足的需求。
方法：AYAs诊断为MBC（18-39岁）参与前瞻性干预研究（Young，授权，和Strong）在Dana-Farber癌症研究所完成了注册后的电子调查。评估社会人口统计学的措施，健康行为,生活质量,和症状，在其他人中。我们使用双边费舍尔精确检验来确定关注点之间的关联(例如，癌症进展,副作用,生活方式,金融,生育率)和人口变量。
结果：在9/2020-12/2022登记的77名参与者中，MBC诊断和调查的平均年龄为35.9岁（范围：22-39岁）和38.3岁（范围：27-46岁）。分别。大多数是非西班牙裔白人（83.8％），40.3％的人报告他们的诊断引起了一些财务问题。许多人担心生育率(27.0%)，长期治疗副作用（67.6%），锻炼(61.6%)，和饮食(54.1%)。选择的关注点因年龄而异，种族/民族,和教育。调查中的年轻女性报告了对家族性癌症风险的更大关注（p=0.028）。来自少数种族/族裔群体的妇女更经常向家人/朋友报告谈论癌症的问题（p=0.040），而受教育程度较高的妇女更经常关注癌症对其健康的长期影响（p=0.021）。
结论：患有MBC的年轻女性经常报告社会心理，健康,和癌症管理问题。定制支持性护理和沟通以解决普遍的问题，包括疾病进展和治疗副作用，可能会优化健康。
方法：AYAs诊断为MBC（18-39岁）参与前瞻性干预研究（Young，授权，和Strong）在Dana-Farber癌症研究所完成了注册后的电子调查。评估社会人口统计学的措施，健康行为,生活质量,和症状，在其他人中。我们使用双边费舍尔精确检验来确定关注点之间的关联(例如，癌症进展,副作用,生活方式,金融,生育率)和人口变量。
结果：在9/2020-12/2022登记的77名参与者中，MBC诊断和调查的平均年龄为35.9岁（范围：22-39岁）和38.3岁（范围：27-46岁）。分别。大多数是非西班牙裔白人（83.8％），40.3％的人报告他们的诊断引起了一些财务问题。许多人担心生育率(27.0%)，长期治疗副作用（67.6%），锻炼(61.6%)，和饮食(54.1%)。选择的关注点因年龄而异，种族/民族,和教育。调查中的年轻女性报告了对家族性癌症风险的更大关注（p=0.028）。来自少数种族/族裔群体的妇女更经常向家人/朋友报告谈论癌症的问题（p=0.040），而受教育程度较高的妇女更经常关注癌症对其健康的长期影响（p=0.021）。
结论：患有MBC的年轻女性经常报告社会心理，健康,和癌症管理问题。定制支持性护理和沟通以解决普遍的问题，包括疾病进展和治疗副作用，可能会优化健康。
