PDF(Pubmed)
Abstract：
Introduction: The possible beneficial effects of physical activity during doxorubicin treatment of breast cancer need further investigation as many of the existing studies have been done on non-tumor-bearing models. Therefore, in this study, we aim to assess whether short-term voluntary wheel-running exercise during doxorubicin treatment of breast cancer-bearing mice could induce beneficial cardiac effects and enhance chemotherapy efficacy. Methods: Murine breast cancer I3TC cells were inoculated subcutaneously to the flank of female FVB mice (n = 16) that were divided into exercised and non-exercised groups. Two weeks later, doxorubicin treatment was started via intraperitoneal administration (5 mg/kg weekly for 3 weeks). Organs were harvested a day after the last dose. Results: The tumor volume over time was significantly different between the groups, with the exercising group having lower tumor volumes. The exercised group had increased body weight gain, tumor apoptosis, capillaries per cardiomyocytes, and cardiac lactate dehydrogenase activity compared to the unexercised group, but tumor blood vessel density and maturation and tumor and cardiac HIF1-α and VEGF-A levels did not differ from those of the non-exercised group. Discussion: We conclude that even short-term light exercise such as voluntary wheel running exercise can decrease the subcutaneous mammary tumor growth, possibly via increased tumor apoptosis. The increase in cardiac capillaries per cardiomyocytes may also have positive effects on cancer treatment outcomes.
摘要：
简介：在阿霉素治疗乳腺癌期间，身体活动的可能有益作用需要进一步研究，因为许多现有的研究已经在非荷瘤模型上进行。因此,在这项研究中，我们的目的是评估在多柔比星治疗乳腺癌小鼠期间的短期自愿轮跑运动是否可以诱导有益的心脏效应并增强化疗疗效.方法：将小鼠乳腺癌I3TC细胞皮下接种到雌性FVB小鼠（n=16）的侧腹，分为运动组和非运动组。两周后,通过腹膜内给药(每周5mg/kg,持续3周)开始阿霉素治疗。在最后一次剂量后一天收获器官。结果:各组间肿瘤体积随时间的变化有显著差异,运动组肿瘤体积较低。运动组体重增加增加，肿瘤凋亡，每个心肌细胞的毛细血管，与未运动组相比，心脏乳酸脱氢酶活性，但是肿瘤血管密度和成熟度以及肿瘤和心脏HIF1-α和VEGF-A水平与非运动组没有差异。讨论：我们得出的结论是，即使是短期的轻度运动，例如自愿的车轮跑步运动，也可以减少皮下乳腺肿瘤的生长。可能通过增加肿瘤细胞凋亡。每个心肌细胞的心脏毛细血管的增加也可能对癌症治疗结果具有积极影响。
