PDF(Pubmed)
Abstract：
OBJECTIVE: Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.
METHODS: This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.
RESULTS: In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (β = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (β = 0.231 [95% CI = 0.124-3.639], p = 0.036).
CONCLUSIONS: Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.
METHODS: This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.
RESULTS: In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (β = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (β = 0.231 [95% CI = 0.124-3.639], p = 0.036).
CONCLUSIONS: Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.
摘要：
目的：特发性正常压力脑积水（iNPH）是一种导致进行性步态和认知障碍的慢性神经系统疾病。我们调查了步态表型是否与iNPH中认知缺陷的严重程度相关。
方法：这项回顾性研究招募了88名患者（平均年龄=76.18±7.21岁，42%女性）。患者最初因怀疑患有iNPH而转诊，并进行了全面分析，包括步态分析和认知评估。
结果：在该队列中（27％的步态正常，25%的额叶步态,16%帕金森步态,27%其他步态异常)，帕金森病和额叶步态患者的简易精神状态检查(MMSE)评分最低,步态速度最慢.步态正常的患者MMSE评分和步态速度最高。额叶步态与较低的MMSE评分相关，即使在调整了年龄之后，性别,合并症,白质病变,和教育水平(β=-0.221[95%置信区间(CI)=-3.718至-0.150]，p=0.034)。正常步态与最佳MMSE评分相关，即使在调整上述变量后(β=0.231[95%CI=0.124-3.639]，p=0.036)。
结论：iNPH患者的步态表型与MMSE评估的整体认知相关。
方法：这项回顾性研究招募了88名患者（平均年龄=76.18±7.21岁，42%女性）。患者最初因怀疑患有iNPH而转诊，并进行了全面分析，包括步态分析和认知评估。
结果：在该队列中（27％的步态正常，25%的额叶步态,16%帕金森步态,27%其他步态异常)，帕金森病和额叶步态患者的简易精神状态检查(MMSE)评分最低,步态速度最慢.步态正常的患者MMSE评分和步态速度最高。额叶步态与较低的MMSE评分相关，即使在调整了年龄之后，性别,合并症,白质病变,和教育水平(β=-0.221[95%置信区间(CI)=-3.718至-0.150]，p=0.034)。正常步态与最佳MMSE评分相关，即使在调整上述变量后(β=0.231[95%CI=0.124-3.639]，p=0.036)。
结论：iNPH患者的步态表型与MMSE评估的整体认知相关。
