空气污染是全球发病率和死亡率的重要因素,并与痴呆症风险增加有关。瑞典北部Betula队列中的先前研究表明,空气污染与痴呆症之间存在关联,以及与对照组相比,痴呆症患者独特的代谢组学特征。这项研究旨在调查空气污染是否与该队列中代谢物水平的定量变化有关,以及未来的痴呆状态是否会改变这种关联。
■使用高空间分辨率模型和实测数据对短期和长期暴露于空气污染进行了评估。分别分析了汽车尾气和木烟对空气的污染。对321名参与者进行了代谢组学分析,包括58份来自痴呆患者的血清样本和一个年龄相匹配的对照组,性别,和教育水平,使用核磁共振波谱。
■在任何代谢物与任何短期或长期暴露于空气污染的措施之间没有发现统计学上的显着关联。然而,有趋势可能提示长期和短期空气污染暴露与乳酸和葡萄糖代谢产物之间存在关联.值得注意的是,尽管该队列中长期和短期空气污染暴露之间缺乏相关性,但仍观察到了这些关联.在参与者中,木烟造成的空气污染之间的关联也有趋势,这些参与者后来会发展为痴呆症,表明取决于城市/农村因素的潜在影响。
■虽然没有发现明显的关联,数据中观察到的趋势表明,空气污染暴露与乳酸和葡萄糖代谢产物的变化之间存在潜在的联系。这些发现为低暴露环境中空气污染与代谢标志物之间的联系提供了一些新的见解。然而,解决现有的局限性对于提高该领域未来研究的鲁棒性和适用性至关重要。后来患上痴呆症的参与者的明显关联可能表明城市/农村因素的影响,保证进一步调查。
UNASSIGNED: Air pollution is a significant contributor to morbidity and mortality globally and has been linked to an increased risk of dementia. Previous studies within the Betula cohort in Northern Sweden have demonstrated associations between air pollution and dementia, as well as distinctive metabolomic profiles in dementia patients compared to controls. This study aimed to investigate whether air pollution is associated with quantitative changes in metabolite levels within this cohort, and whether future dementia status would modify this association.
UNASSIGNED: Both short-term and long-term exposure to air pollution were evaluated using high spatial resolution models and measured data. Air pollution from vehicle exhaust and woodsmoke were analyzed separately. Metabolomic profiling was conducted on 321 participants, including 58 serum samples from dementia patients and a control group matched for age, sex, and education level, using nuclear magnetic resonance spectroscopy.
UNASSIGNED: No statistically significant associations were found between any metabolites and any measures of short-term or long-term exposure to air pollution. However, there were trends potentially suggesting associations between both long-term and short-term exposure to air pollution with lactate and glucose metabolites. Notably, these associations were observed despite the lack of correlation between long-term and short-term air pollution exposure in this cohort. There were also tendencies for associations between air pollution from woodsmoke to be more pronounced in participants that would later develop dementia, suggesting a potential effect depending on urban/rural factors.
UNASSIGNED: While no significant associations were found, the trends observed in the data suggest potential links between air pollution exposure and changes in lactate and glucose metabolites. These findings provide some new insights into the link between air pollution and metabolic markers in a low-exposure setting. However, addressing existing limitations is crucial to improve the robustness and applicability of future research in this area. The pronounced associations in participants who later developed dementia may indicate an influence of urban/rural factors, warranting further investigation.