PDF(Pubmed)
Abstract：
Apolipoprotein E (ApoE) has been associated with several diseases including Parkinson\'s disease, Alzheimer\'s and multiple sclerosis. ApoE also has documented immunomodulatory functions. We investigated gene expression in circulating monocytes and in bone marrows of patients with visceral leishmaniasis (VL) living in an endemic area in Bihar, India, and contrasted these with control healthy subjects or other diagnostic bone marrows from individuals in the same region. Samples from VL patients were obtained prior to initiating treatment. Our study revealed significant upregulated expression of the apoE transcript in patients with VL. Furthermore, the levels of ApoE protein were elevated in serum samples of subjects with VL compared with healthy endemic controls. These observations may provide clues regarding the complex interactions between lipid metabolism and immunoregulation of infectious and inflammatory diseases.
摘要：
载脂蛋白E(ApoE)与包括帕金森病在内的多种疾病有关,老年痴呆症和多发性硬化症。ApoE也有免疫调节功能。我们研究了生活在比哈尔邦流行地区的内脏利什曼病（VL）患者的循环单核细胞和骨髓中的基因表达，印度,并将这些与对照健康受试者或来自同一地区个体的其他诊断骨髓进行对比。在开始治疗之前从VL患者获得样品。我们的研究表明，VL患者中apoE转录本的表达显着上调。此外，与健康地方对照相比，VL患者的血清样本中ApoE蛋白水平升高。这些观察结果可能为脂质代谢与感染性和炎症性疾病的免疫调节之间的复杂相互作用提供线索。
