PDF(Pubmed)
Abstract：
BACKGROUND: Autism spectrum disorder has been linked to a variety of organizational and developmental deviations in the brain. One such organizational difference involves hemispheric lateralization, which may be localized to language-relevant regions of the brain or distributed more broadly.
METHODS: In the present study, we estimated brain hemispheric lateralization in autism based on each participant\'s unique functional neuroanatomy rather than relying on group-averaged data. Additionally, we explored potential relationships between the lateralization of the language network and behavioral phenotypes including verbal ability, language delay, and autism symptom severity. We hypothesized that differences in hemispheric asymmetries in autism would be limited to the language network, with the alternative hypothesis of pervasive differences in lateralization. We tested this and other hypotheses by employing a cross-sectional dataset of 118 individuals (48 autistic, 70 neurotypical). Using resting-state fMRI, we generated individual network parcellations and estimated network asymmetries using a surface area-based approach. A series of multiple regressions were then used to compare network asymmetries for eight significantly lateralized networks between groups.
RESULTS: We found significant group differences in lateralization for the left-lateralized Language (d = -0.89), right-lateralized Salience/Ventral Attention-A (d = 0.55), and right-lateralized Control-B (d = 0.51) networks, with the direction of these group differences indicating less asymmetry in autistic males. These differences were robust across different datasets from the same participants. Furthermore, we found that language delay stratified language lateralization, with the greatest group differences in language lateralization occurring between autistic males with language delay and neurotypical individuals.
CONCLUSIONS: These findings evidence a complex pattern of functional lateralization differences in autism, extending beyond the Language network to the Salience/Ventral Attention-A and Control-B networks, yet not encompassing all networks, indicating a selective divergence rather than a pervasive one. Moreover, we observed an association between Language network lateralization and language delay in autistic males.
METHODS: In the present study, we estimated brain hemispheric lateralization in autism based on each participant\'s unique functional neuroanatomy rather than relying on group-averaged data. Additionally, we explored potential relationships between the lateralization of the language network and behavioral phenotypes including verbal ability, language delay, and autism symptom severity. We hypothesized that differences in hemispheric asymmetries in autism would be limited to the language network, with the alternative hypothesis of pervasive differences in lateralization. We tested this and other hypotheses by employing a cross-sectional dataset of 118 individuals (48 autistic, 70 neurotypical). Using resting-state fMRI, we generated individual network parcellations and estimated network asymmetries using a surface area-based approach. A series of multiple regressions were then used to compare network asymmetries for eight significantly lateralized networks between groups.
RESULTS: We found significant group differences in lateralization for the left-lateralized Language (d = -0.89), right-lateralized Salience/Ventral Attention-A (d = 0.55), and right-lateralized Control-B (d = 0.51) networks, with the direction of these group differences indicating less asymmetry in autistic males. These differences were robust across different datasets from the same participants. Furthermore, we found that language delay stratified language lateralization, with the greatest group differences in language lateralization occurring between autistic males with language delay and neurotypical individuals.
CONCLUSIONS: These findings evidence a complex pattern of functional lateralization differences in autism, extending beyond the Language network to the Salience/Ventral Attention-A and Control-B networks, yet not encompassing all networks, indicating a selective divergence rather than a pervasive one. Moreover, we observed an association between Language network lateralization and language delay in autistic males.
摘要：
背景：自闭症谱系障碍与大脑中的各种组织和发育偏差有关。一个这样的组织差异涉及半球偏侧化，可能位于大脑的语言相关区域或更广泛地分布。
方法：在本研究中，我们根据每个参与者独特的功能神经解剖学而不是依赖于群体平均数据,估计了自闭症患者的大脑半球偏侧化.此外,我们探索了语言网络的侧化与行为表型之间的潜在关系，包括言语能力，语言延迟，和自闭症症状的严重程度。我们假设自闭症中半球不对称性的差异将仅限于语言网络，与偏侧化普遍存在差异的另一种假设。我们通过使用118名个体的横截面数据集（48名自闭症患者，70神经典型)。使用静息状态功能磁共振成像，我们使用基于表面积的方法生成单个网络分组并估计网络不对称性。然后使用一系列多元回归来比较组之间八个显着横向化网络的网络不对称性。
结果：我们发现左侧语言的侧化存在显着差异（d=-0.89），右侧显着性/腹侧注意力-A(d=0.55)，和右侧化控制B(d=0.51)网络，这些群体差异的方向表明自闭症男性的不对称性较小。这些差异在来自同一参与者的不同数据集上是稳健的。此外，我们发现语言延迟分层语言偏侧化，语言偏侧化的最大群体差异发生在有语言延迟的自闭症男性和神经典型个体之间。
结论：这些发现证明了自闭症患者功能偏侧化差异的复杂模式，从语言网络延伸到显著性/腹侧注意力A和控制B网络，但并不包括所有的网络，表明有选择性的分歧，而不是普遍的分歧。此外，我们观察到自闭症男性的语言网络偏侧化与语言延迟之间存在关联。
方法：在本研究中，我们根据每个参与者独特的功能神经解剖学而不是依赖于群体平均数据,估计了自闭症患者的大脑半球偏侧化.此外,我们探索了语言网络的侧化与行为表型之间的潜在关系，包括言语能力，语言延迟，和自闭症症状的严重程度。我们假设自闭症中半球不对称性的差异将仅限于语言网络，与偏侧化普遍存在差异的另一种假设。我们通过使用118名个体的横截面数据集（48名自闭症患者，70神经典型)。使用静息状态功能磁共振成像，我们使用基于表面积的方法生成单个网络分组并估计网络不对称性。然后使用一系列多元回归来比较组之间八个显着横向化网络的网络不对称性。
结果：我们发现左侧语言的侧化存在显着差异（d=-0.89），右侧显着性/腹侧注意力-A(d=0.55)，和右侧化控制B(d=0.51)网络，这些群体差异的方向表明自闭症男性的不对称性较小。这些差异在来自同一参与者的不同数据集上是稳健的。此外，我们发现语言延迟分层语言偏侧化，语言偏侧化的最大群体差异发生在有语言延迟的自闭症男性和神经典型个体之间。
结论：这些发现证明了自闭症患者功能偏侧化差异的复杂模式，从语言网络延伸到显著性/腹侧注意力A和控制B网络，但并不包括所有的网络，表明有选择性的分歧，而不是普遍的分歧。此外，我们观察到自闭症男性的语言网络偏侧化与语言延迟之间存在关联。
