PDF(Pubmed)
Abstract：
BACKGROUND: HIV is a major public health issue affecting millions globally. Women and girls account for 46% of new HIV infections in 2022 and approximately 1.3 million females become pregnant every year. Vertical transmission of HIV from persons living with HIV (PLHIV) to infants may occur through different modalities, such as through breast/chest feeding. Notably, 82% of PLHIV who chose to breast/chest feed are on antiretroviral therapy (ART) when feeding their infants. Precise estimates of the risk of postpartum transmission to infants during breast/chest feeding at varying viral load levels remain a significant gap in the literature.
METHODS: A rapid systematic search of electronic databases will be conducted from January 2005 to the present, including Medline, Embase and Global Health. The objective of this rapid review is to explore and assess the available evidence on the effect of varying viral load levels on the risk of HIV transmission to infants during breast/chest feeding when the birthing or gestational parent living with HIV is on ART. Study characteristics will be summarised and reported to support the narrative summary of the findings. The focus will be on the absolute risk of HIV transmission from birthing parent to infant during chest/breast feeding. The findings will also be stratified by month, including the risk of HIV transmission for 6 months and greater than 6 months postpartum. We will ascertain the risk of bias using A Measurement Tool to Assess Systematic Reviews 2, Quality of Prognosis Studies and Downs and Black checklist for the appropriate study type. A summary score will not be calculated, rather the strengths and limitations of the studies will be narratively described.
BACKGROUND: No human subjects will be involved in the research. The findings of this rapid review will inform a future systematic review and will be disseminated through peer-reviewed publications, presentations and conferences.
UNASSIGNED: CRD42024499393.
METHODS: A rapid systematic search of electronic databases will be conducted from January 2005 to the present, including Medline, Embase and Global Health. The objective of this rapid review is to explore and assess the available evidence on the effect of varying viral load levels on the risk of HIV transmission to infants during breast/chest feeding when the birthing or gestational parent living with HIV is on ART. Study characteristics will be summarised and reported to support the narrative summary of the findings. The focus will be on the absolute risk of HIV transmission from birthing parent to infant during chest/breast feeding. The findings will also be stratified by month, including the risk of HIV transmission for 6 months and greater than 6 months postpartum. We will ascertain the risk of bias using A Measurement Tool to Assess Systematic Reviews 2, Quality of Prognosis Studies and Downs and Black checklist for the appropriate study type. A summary score will not be calculated, rather the strengths and limitations of the studies will be narratively described.
BACKGROUND: No human subjects will be involved in the research. The findings of this rapid review will inform a future systematic review and will be disseminated through peer-reviewed publications, presentations and conferences.
UNASSIGNED: CRD42024499393.
摘要：
背景：HIV是影响全球数百万人的重大公共卫生问题。2022年，妇女和女孩占新的艾滋病毒感染人数的46%，每年约有130万女性怀孕。艾滋病毒从艾滋病毒感染者（PLHIV）向婴儿的垂直传播可能通过不同的方式发生，例如通过乳房/胸部喂养。值得注意的是,82％选择母乳喂养/胸部喂养的PLHIV在喂养婴儿时接受抗逆转录病毒疗法（ART）。在不同的病毒载量水平下，对母乳喂养/胸部喂养期间产后传播给婴儿的风险的精确估计在文献中仍然存在很大差距。
方法:从2005年1月至今,将对电子数据库进行快速系统检索,包括Medline,Embase和全球健康。这项快速审查的目的是探索和评估有关不同病毒载量水平对感染艾滋病毒的分娩或妊娠父母在接受ART治疗时在乳房/胸部喂养期间将艾滋病毒传播给婴儿的风险的影响的现有证据。将总结和报告研究特征，以支持研究结果的叙述性总结。重点将是在胸部/母乳喂养期间从分娩父母向婴儿传播艾滋病毒的绝对风险。调查结果也将按月分层，包括产后6个月和大于6个月的HIV传播风险。我们将使用测量工具来确定偏倚的风险，以评估系统评论2，预后研究的质量以及适当研究类型的Downs和Black核对表。不会计算汇总分数，相反，将叙述这些研究的优点和局限性。
背景：没有人类受试者参与研究。这一快速审查的结果将为今后的系统审查提供信息，并将通过同行审查的出版物传播，演讲和会议。
■CRD42024499393。
方法:从2005年1月至今,将对电子数据库进行快速系统检索,包括Medline,Embase和全球健康。这项快速审查的目的是探索和评估有关不同病毒载量水平对感染艾滋病毒的分娩或妊娠父母在接受ART治疗时在乳房/胸部喂养期间将艾滋病毒传播给婴儿的风险的影响的现有证据。将总结和报告研究特征，以支持研究结果的叙述性总结。重点将是在胸部/母乳喂养期间从分娩父母向婴儿传播艾滋病毒的绝对风险。调查结果也将按月分层，包括产后6个月和大于6个月的HIV传播风险。我们将使用测量工具来确定偏倚的风险，以评估系统评论2，预后研究的质量以及适当研究类型的Downs和Black核对表。不会计算汇总分数，相反，将叙述这些研究的优点和局限性。
背景：没有人类受试者参与研究。这一快速审查的结果将为今后的系统审查提供信息，并将通过同行审查的出版物传播，演讲和会议。
■CRD42024499393。
