Abstract：
This study aims to analyze the clinical and immunologic features of SLE in Jordan, while also investigating the impact of age and gender on disease presentation. The study included 275 patients diagnosed with SLE. Data were collected through meticulous patient interviews and thorough examination of patient hospital records. The cohort exhibited a mean age of 36.8 ± 12.9 years, with an average disease duration of 7.0 ± 7.8 years. The mean age at diagnosis was 29.9 ± 12.1 years, and the female to male ratio was 7.8:1. The most frequently observed symptoms were arthralgia (90.2%), fatigue (80.7%), hematologic manifestations (62%), photosensitivity (60.7%), Raynaud\'s phenomenon (53.5%), and malar rash (50.9%). The frequencies of various autoantibodies were as follows: ANA (96.7%), anti-dsDNA (39.6%), anti-SSA/Ro (32.8%), anti-Sm (21.8%), anti-U1-RNP (20.6%), and anti-SSB/La (15.5%). Male patients tended to receive a diagnosis at a younger age and exhibited a higher likelihood of experiencing severe manifestations compared to females. Additionally, juvenile onset patients demonstrated an increased likelihood of fever, photosensitivity, myositis, and anti-dsDNA autoantibodies, while adult onset patients were more predisposed to having anti-Ro, anti-La, and RF autoantibodies. This study reveals that the most prevalent manifestations of SLE in the Jordanian cohort encompassed arthralgia, fatigue, and hematologic manifestations. The prevalence of alopecia and Raynaud\'s phenomenon exceeded that observed in other published cohorts, while arthritis and discoid rash were less frequently encountered. The study highlights that males are more susceptible to developing severe manifestations of SLE compared to females.
摘要：
本研究旨在分析约旦SLE的临床和免疫学特征。同时调查年龄和性别对疾病表现的影响。该研究包括275例诊断为SLE的患者。通过细致的患者访谈和对患者医院记录的全面检查来收集数据。该队列的平均年龄为36.8±12.9岁，平均病程7.0±7.8年。诊断时的平均年龄为29.9±12.1岁，男女比例为7.8:1。最常见的症状是关节痛（90.2%），疲劳(80.7%)，血液学表现（62%），光敏性（60.7%），雷诺现象（53.5%），及黄斑疹(50.9%)。各种自身抗体的频率如下：ANA（96.7%），抗dsDNA（39.6%），抗SSA/Ro（32.8%），反Sm（21.8%），反U1-RNP（20.6%），和抗SSB/La（15.5%）。与女性相比，男性患者倾向于在更年轻的年龄接受诊断，并且表现出更高的严重表现可能性。此外,青少年发病患者表现出发烧的可能性增加，光敏性,肌炎,和抗dsDNA自身抗体，而成年发病患者更倾向于抗Ro，反La,和RF自身抗体。这项研究表明，在约旦队列中，SLE最普遍的表现包括关节痛，疲劳,和血液学表现。脱发和雷诺现象的患病率超过了其他已发表的队列中观察到的，而关节炎和盘状皮疹的发生率较低。该研究强调，与女性相比，男性更容易出现严重的SLE表现。
